A recent study followed 515 patients with varying cancers. The goal was to evaluate if patients had an immune response to the Moderna mRNA-1273 vaccine and if that response differed by diagnosis and treatment.

New research has identified that the frequently used chemotherapy drug (5-FU or Fluorouracil) is 100 per cent more effective at targeting tumors (rather than surrounding tissues) when administered using an optimized liposomal formulation.

With the resurgence of interest in cancer metabolism, researchers are coming to realize that there is more to a cell’s biochemistry than once thought.

Scientists may better understand and test for the genetic variations that cause cancer and other heritable diseases through the application of federated analysis, a novel strategy for securely sharing and analyzing genomic data developed at the UC Santa Cruz Genomics Institute.

Metastatic cells form in a primary tumor and then break away from it, migrate to other organs, attach to them and form new tumors. This spread reduces patients‘ chances of recovery. Scientists have discovered some of the mechanisms by which these cells arise. This is due to cells that have narrowly escaped cell death (apoptosis) following a chemotherapeutic treatment. Those cells reprogram themselves to acquire metastatic skills. Thanks to this study, these cells – called PAME by the researchers – now appear as new therapeutic targets.

Amyloid beta, a protein known to build-up in the brains of Alzheimer’s patients, also helps skin cancer cells thrive when they spread to the brain, a new study finds.

Researchers have successfully leveraged an FDA-approved drug to halt growth of tumors driven by mutations in the RAS gene, which are famously difficult to treat and account for about one in four cancer deaths.

A researcher has made a discovery that alters our understanding of how the body’s DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders. Researchers discovered that base excision repair has a built-in mechanism to increase its effectiveness — it just needs to be captured at a very precise point in the cell life cycle.

Squeezing through tight spaces makes cancer cells more aggressive and helps them evade cell death, shows a new study.

Women who have had one ovary surgically removed (unilateral oophorectomy) are less likely to become pregnant after in vitro fertilization and give birth to fewer babies than women with both ovaries. That is according to an extensive meta-analysis.

A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a new study. The findings might someday lead to a way to regenerate brain tissue after disease or injury.

Researchers developed an algorithm estimating a person’s risk of developing prostate cancer based on age and the levels of two prostate cancer markers, PSA and hK2 (human kalliknein peptidase). They found that, by setting a risk threshold above which men are counted as ’screen positive‘, the approach would reduce the number of false positives by three quarters compared to a standard PSA test, while catching the same proportion of cancers.

Scientists determined that 9/11 first responders to the World Trade Center have increased levels of mutations that escalate their risk for blood cancers or cardiovascular disease, according to a new study.

Researchers demonstrate that combinations of antiviral drugs inhibiting both polymerase and exonuclease reduce SARS-CoV-2 replication 10 times more than polymerase inhibitors alone.

A new study — in mice — suggests that blocking a major inflammatory pathway that is activated in pancreatic cancer makes the tumors sensitive to chemotherapy and a type of immunotherapy that prompts the immune system’s T cells to attack the cancer cells. The therapy more than doubled survival in a mouse model of pancreatic cancer.

Investigators have discovered how a drug for multiple sclerosis interacts with its targets, a finding that may pave the way for better treatments.

Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients and classification of future cancer risk.

For years, surgery for patients with stage III melanoma — melanoma that has spread to the lymph nodes — involved removing those lymph nodes along with the primary tumor. Known as completion lymph node dissection (CLND), the surgery was meant to ensure that no cancer remained after surgery. More recently, however, cancer surgeons have discovered that CLND has the potential to cause more problems than it solves. In most cases, patients do better on immunotherapy alone than they do when their surgery involves removal of the lymph nodes, due to potential complications from lymph node surgery.

A new meta-analysis, or data examination of several independent studies, adds to evidence that taller adults may be more likely than shorter ones to develop colorectal cancer or colon polyps that can later become malignant.

Bioengineers have shown they can eradicate advanced-stage ovarian and colorectal cancer in mice in as little as six days with a treatment that could be ready for human clinical trials later this year.

As of today, there is no vaccine against hepatitis C. To improve the search for it, researchers are looking for a so-called surrogate model: an animal that can also suffer from viral hepatitis and whose course of infection allows conclusions about the behavior of the hepatitis C virus in humans. They found what they were looking for in the horse.

It may be possible to identify the presence of an aggressive brain tumor in children by studying their cerebrospinal fluid, according to new research.

Multiple myeloma, the most common type of bone marrow cancer in Germany, almost always returns, even after initial treatment success. In the majority of cases, the reasons behind this treatment resistance (e.g., genetic mutations) and the subsequent return of the disease, remain unknown. According to new research, it is the increased production of a specific protein which diminishes the cancer’s sensitivity to treatment.

The largest study to date has confirmed the link between the gut microbiome and the response to cancer immunotherapy therapy for melanoma.

A clinical trial has shown that the immunotherapy drug pembrolizumab increased survival rates for head and neck cancer patients with intermediate risk.