Schlagwort: population
Dynamic Population Breeding Improves Turquoise Killifish Husbandry
The short lifespan of the turquoise killifish (N. furzeri) makes it an important model organism for aging research. However, its husbandry and breeding present research institutions with challenges: The fish have a short lifespan and must be continuously bred, while at the same time their genetic diversity must be preserved. Researchers at the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) have therefore developed the Dynamic Population Breeding (DPB) method. This new breeding concept improves the survival rate of offspring, reduces differences between breeding cohorts, and thus creates an important foundation for reproducible and sustainable research on biological aging….
Dynamic Population Breeding verbessert die Haltung des Türkisen Prachtgrundkärpflings
Der Türkise Prachtgrundkärpfling (N. furzeri) ist aufgrund seiner kurzen Lebensspanne ein wichtiger Modellorganismus in der Alternsforschung. Seine Haltung und Zucht stellen Forschungseinrichtungen jedoch vor besondere Herausforderungen: Die Tiere altern schnell und müssen kontinuierlich nachgezüchtet werden, gleichzeitig soll ihre genetische Vielfalt aber erhalten bleiben. Forschende des Leibniz-Instituts für Alternsforschung (FLI) haben das Dynamic Population Breeding entwickelt. Es verbessert die Überlebensrate der Nachkommen, reduziert Unterschiede zwischen den Zuchtkohorten und schafft so eine wichtige Grundlage für eine reproduzierbare, nachhaltige Forschung zum biologischen Altern. Quelle: IDW Informationsdienst Wissenschaft
University researchers join forces with industry partners to keep people healthy and independent for longer
Continuous monitoring of indoor air to assess health and wellbeing, smart sheets that monitor sleep quality and miniaturized hearing aids – international partners in academia and industry are collaborating on the SensorTech4Health 2030 project to develop novel technology that monitors the surrounding environment to continuously gauge health. Against the backdrop of an ageing population and high care costs, the project sets out to use prevention to help people remain fit and independent for longer. Bosch Sensortec is coordinating the project, which has received 15 million euros from national funding organizations within the EUREKA Cluster Xecs. Quelle: IDW Informationsdienst Wissenschaft
Ebola outbreak in the Democratic Republic of the Congo and Uganda: Current assessment of the epidemic situation
The World Health Organization (WHO) has declared the current Ebola outbreak in the Democratic Republic of the Congo (DR Congo) and Uganda a public health emergency of international concern. The outbreak is caused by the rare Bundibugyo virus, a member of the Ebolavirus genus, for which neither an approved vaccine nor a specific treatment is currently available. International health authorities are monitoring the situation closely. According to assessments by the European Centre for Disease Prevention and Control (ECDC) and the Robert Koch Institute (RKI), there is currently only a very low risk to the population in Germany. Quelle: IDW Informationsdienst…
New cell population discovered in the brains of Alzheimer’s patients
Scientists at the Institute of Anatomy at Leipzig University, working together with international research institutions, have identified a previously unknown group of immune cells in the brain tissue of people with Alzheimer’s disease. This discovery was made possible by a newly developed microscopy technique that has, for the first time, been specifically optimised for the human brain. The findings have been published in the prestigious journal Nature Neuroscience. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …
Insights into the Alzheimer’s brain: previously unknown population of immune cells discovered
A newly developed microscopy technique allows for the first tim, visualising more than 30 protein markers simultaneously in the human brain and to use bioinformatics to analyse their spatial relationships. In the process, the researchers have discovered a previously unknown population of immune cells in the brains of Alzheimer’s patients, which is found almost exclusively in the vicinity of a specific type of pathological protein deposit. The newly developed method could, in future, bring about lasting changes not only in Alzheimer’s research but also in the investigation of tumours and other diseases. The research findings have just been published in…
Einblicke ins Alzheimer-Gehirn: bislang unbekannte Immunzell-Population gefunden
Eine neu entwickelte Mikroskopiertechnologie erlaubt es erstmals, mehr als 30 Protein-Marker gleichzeitig im menschlichen Gehirn sichtbar zu machen und bioinformatisch deren Lagebeziehungen zueinander zu untersuchen. Dabei wurde eine bislang unbekannte Immunzell-Population im Gehirn von Alzheimer-Erkrankten entdeckt, die nahezu ausschließlich in der Umgebung einer bestimmten Form von krankhaften Proteinablagerungen zu finden ist. Die neue Methode könnte auch die Untersuchung von Tumoren und das Erforschen anderer Erkrankungen nachhaltig verändern. Die Forschungsergebnisse wurden soeben in der renommierten Fachzeitschrift Nature Neuroscience veröffentlicht. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …
After the Fall of Rome: How the Population of Central Europe Emerged
An international study based on Bavarian findings shows that southern Germany‘s population after the collapse of the Roman Empire developed through the gradual intermingling of different groups and regional mobility—not through single large-scale migrations. The study has now been published in the prestigious journal Nature. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …
AI-driven analysis of atrial fibrillation burden in pacemaker patients reveals no effect of AF burden on stroke
An analysis of the NOAH – AFNET 6 trial used large language models to extract AF burden from pacemaker data in patients with device-detected atrial fibrillation. This approach enables to evaluate the impact of AF burden on cardiovascular outcome and on the effectiveness and safety of anticoagulation in pacemaker patients. The AF burden in the population was 0.4%, with 20% of patients showing a baseline AF burden of more than 1%. In these patients, there was no effect of AF burden on stroke or other cardiovascular events. Today, the findings were presented by AFNET board member Prof. Ulrich Schotten, Maastricht,…
KI-gestützte Analyse bei Herzschrittmacherpatient:innen zeigt: Vorhofflimmerlast hat keinen Einfluss auf Schlaganfälle
Eine Analyse der NOAH – AFNET 6 Studie setzte große Sprachmodelle ein, um bei Patient:innen mit Device-detektiertem Vorhofflimmern aus Herzschrittmacherdaten die Vorhofflimmerlast zu ermitteln. Dieser Ansatz ermöglicht es, den Einfluss der Vorhofflimmerlast auf den kardiovaskulären Zustand sowie auf die Wirksamkeit und Sicherheit der Antikoagulation bei Herzschrittmacherpatient:innen zu bewerten. Die Vorhofflimmerlast in der Population betrug 0,4 Prozent, wobei 20 Prozent der Patient:innen eine Ausgangs-Vorhofflimmerlast von mehr als 1 Prozent aufwiesen. Bei diesen Patient:innen zeigt sich kein Einfluss der Vorhofflimmerlast auf Schlaganfälle oder andere kardiovaskuläre Ereignisse. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci
Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer1, Lothar Schermelleh and Marion Cremer Abstract Background A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome territories (CTs) in human and mouse somatic cells, and explored the spatio-temporal process of Barr body formation at onset of inactivation in early differentiating mouse embryonic stem cells (ESCs)….