An analysis of the NOAH – AFNET 6 trial used large language models to extract AF burden from pacemaker data in patients with device-detected atrial fibrillation. This approach enables to evaluate the impact of AF burden on cardiovascular outcome and on the effectiveness and safety of anticoagulation in pacemaker patients. The AF burden in the population was 0.4%, with 20% of patients showing a baseline AF burden of more than 1%. In these patients, there was no effect of AF burden on stroke or other cardiovascular events. Today, the findings were presented by AFNET board member Prof. Ulrich Schotten, Maastricht,…

Eine Analyse der NOAH – AFNET 6 Studie setzte große Sprachmodelle ein, um bei Patient:innen mit Device-detektiertem Vorhofflimmern aus Herzschrittmacherdaten die Vorhofflimmerlast zu ermitteln. Dieser Ansatz ermöglicht es, den Einfluss der Vorhofflimmerlast auf den kardiovaskulären Zustand sowie auf die Wirksamkeit und Sicherheit der Antikoagulation bei Herzschrittmacherpatient:innen zu bewerten. Die Vorhofflimmerlast in der Population betrug 0,4 Prozent, wobei 20 Prozent der Patient:innen eine Ausgangs-Vorhofflimmerlast von mehr als 1 Prozent aufwiesen. Bei diesen Patient:innen zeigt sich kein Einfluss der Vorhofflimmerlast auf Schlaganfälle oder andere kardiovaskuläre Ereignisse. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Europe’s dependence on fossil fuels is not only making the continent economically and politically vulnerable, it also has dramatic consequences for the population’s health. Growing air pollution, heat damage and the climate-related spread of infectious diseases are looming, warns the 2026 Europe Report of the Lancet Countdown on Health and Climate Change, which its co-directors Prof. Dr Joacim Rocklöv and Prof. Dr Cathryn Tonne are about to present to the public. Together with other experts from academia, practice and policy they will discuss the report’s results during a public event at Heidelberg University. The launch event with livestreaming is to…

In an unprecedented field experiment, an international research team led by Goethe University Frankfurt, the University of California, Berkeley, and CNRS Montpellier investigated the evolutionary adaptation of thale cress (Arabidopsis thaliana) to a wide range of climates, from the Alps to the Negev Desert. At 30 locations worldwide, team members sowed the plants, monitored their development, and analyzed genetic changes. The result: many Arabidopsis populations rapidly adapted to local climates – some, however, went extinct. The findings demonstrate how genetic diversity ensures population survival. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

New study from the Senckenberg Nature Research Society and the University of Tübingen illustrates huge upheavals in Neanderthals’ genetic history Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

• 60-fold greater efficacy than standard medication • Results achieved in laboratory and animal studies • 43 percent of the global population infected with H. pylori A significant step toward the potential prevention of stomach cancer: Researchers at the Technical University of Munich (TUM) have increased the effectiveness of a standard antibiotic by a factor of 60 through targeted chemical modifications. In laboratory and animal studies, the new drug candidate successfully combats the bacterium Helicobacter pylori, which is closely associated with the development of stomach cancer. The study findings were published in the journal Nature Microbiology. Quelle: IDW Informationsdienst Wissenschaft

Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer1, Lothar Schermelleh and Marion Cremer Abstract Background A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome territories (CTs) in human and mouse somatic cells, and explored the spatio-temporal process of Barr body formation at onset of inactivation in early differentiating mouse embryonic stem cells (ESCs)….