• Multi-day gene activity profiles from the same cells • Long-term analysis of cell communication in mixed cultures • Potential applications in organoids and tumor microenvironments Until now, studying the genetic processes in cells required destroying them – making it impossible to observe these processes over extended periods of time. A team from the Technical University of Munich (TUM) and Helmholtz Munich has developed a new method to repeatedly obtain up-to-date genetic information from living cells. In the future, this will enable better monitoring of stem cells for therapies or the effects of drugs within cells. Quelle: IDW Informationsdienst Wissenschaft…

Stem-cell memory T (TSCM) cells are able to self-renew, persist long term, and mount potent anti-tumor responses. These properties make them attractive for next-generation CAR T-cell therapies. However, their clinical potential has not previously been demonstrated in humans. A team of researchers co-led by Professor Luca Gattinoni from the Leibniz Institute for Immunotherapy (LIT) and Dr. James Kochenderfer from the National Cancer Institute has published a new study in Cell reporting, for the first time, that CAR T cells designed to acquire a TSCM phenotype demonstrate a favorable safety profile and can induce complete remissions at remarkably low doses without…

Researchers showed that the level of synaptic impairment seen in stem cell-derived neurons of schizophrenia patients, generated from blood samples, predicted their level of cognitive impairment. This is the first time that researchers could show an intraindividual mechanistic explanation for the individual degree of schizophrenia’s cognitive symptoms. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

DKMS recognizes outstanding research and supports young scientists in the field of stem cell transplantation and cell therapy for hematological diseases at the conference of the European Society For Blood And Marrow Transplantation (EBMT) in Madrid. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to bad luck, that is, random mutations arising during DNA replication in normal, noncancerous stem cells. Tomasetti C, Vogelstein B (2015): Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2 January 2015:…

Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer1, Lothar Schermelleh and Marion Cremer Abstract Background A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome territories (CTs) in human and mouse somatic cells, and explored the spatio-temporal process of Barr body formation at onset of inactivation in early differentiating mouse embryonic stem cells (ESCs)….