EBiSC2 and FAIRplus are improving FAIRness of stem cell data

The FAIRplus and EBiSC2 projects are joining forces to improve how ‘FAIR’ standards (Findability, Accessibility, Interoperability and Reusability) can be applied to human induced Pluripotent Stem Cell (iPSC) line data. The joint effort will improve how iPSC line data can be made more findable, standardized and reusable for researchers.

Quelle: IDW Informationsdienst Wissenschaft

Double agents: How stomach stem cells change allegiance upon injury

A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response. Scientists at IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, demonstrate that these functions are two sides of a coin. Upon injury, one “molecular switch” is enough to propel the stem cells from one state to the other. The findings, now published in Cell Stem Cell, could be instrumental in improving our understanding of gastric pathologies.

Quelle: IDW Informationsdienst Wissenschaft

Comprehensive map of human blood stem cell development

Scientists have created a new roadmap that traces each step in the development of blood stem cells in the human embryo, providing scientists with a blueprint for producing fully functional blood stem cells in the lab. The research could help expand treatment options for blood cancers like leukemia and inherited blood disorders such as sickle cell disease.

Quelle: Sciencedaily

Study finds 10-second videos predict blood cancer relapse

Ten-second videos of white blood cell motion in the skin’s microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.

Quelle: Sciencedaily

Researchers identify key regulator of blood stem cell development

A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study.

Quelle: Sciencedaily

Two New Studies for Better Chances of Recovery after Stem Cell Transplantation

The most dangerous side effect of allogeneic blood stem cell transplantation, graft-versus-host disease (GvHD), has still not been sufficiently researched. The world’s largest blood stem cell donor center DKMS wants to change that – it is the declared goal of the non-profit organization to improve the survival and healing chances of blood cancer patients. In the fight against GvHD, DKMS research teams have now launched two new scientific studies.

Quelle: IDW Informationsdienst Wissenschaft

Stem cell discoveries hold potential to improve cancer treatment

Recent discoveries by stem cell scientists may help make cancer treatment more efficient and shorten the time it takes for people to recover from radiation and chemotherapy.

Quelle: Sciencedaily

New graft strategy may improve outcomes for blood stem cell recipients

Removing one type of T cell from donor blood used for stem cell grafts could greatly reduce a serious complication called graft-versus-host disease in patients with leukemia, according to a new study.

Quelle: Sciencedaily

New potential treatment for graft-versus-host-disease and other inflammatory disorders

Researchers have shown that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease, an inflammatory condition that develops in patients after their allogeneic hematopoietic stem cell transplantation.

Quelle: Sciencedaily

New technique may lead to safer stem cell transplants

Studying mice, researchers have developed a method of stem cell transplantation that does not require radiation or chemotherapy. Instead, the strategy takes an immunotherapeutic approach, combining the targeted elimination of blood-forming stem cells in the bone marrow with immune-modulating drugs to prevent the immune system from rejecting the new donor stem cells.

Quelle: Sciencedaily

Die Kunst des künstlichen Gewebes

Der Hilde Mangold Award – ein posthumes Denkmal für die deutsche Embryologin Hilde Mangold – wird jährlich an herausragende Stammzellforscherinnen durch das German Stem Cell Network (GSCN) verliehen. Mit dem Preis werden sowohl die wissenschaftlichen Errungenschaften, als auch das Lebenswerk der Preisträgerin als Vorbild für junge Wissenschaftlerinnen gewürdigt. Dieses Jahr darf Frau Prof. Dr. Katja Schenke-Layland, Direktion des NMI Naturwissenschaftlichen und Medizinischen Instituts in Reutlingen und Professorin für Medizintechnik und Regenerative Medizin an der Medizinischen Fakultät der Eberhard-Karls-Universität in Tübingen diesen Preis in Empfang nehmen.

Quelle: IDW Informationsdienst Wissenschaft

Researchers discover key stem cell dormancy mechanism which could help unlock future cancer treatments

Researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers.

Quelle: Sciencedaily

Sensing ‚junk‘ RNA after chemotherapy enhances blood regeneration

Scientists reveal that during hematopoietic regeneration, RNA expressed from a part of the genome considered ‚junk DNA‘ is used by hematopoietic stem cells to get activated and proliferate. The study shows that these so-called transposable elements make RNA after chemotherapy and activate an immune receptor which induces inflammatory signals enhancing hematopoietic stem cell cycling and thus participating in the regeneration of the hematopoietic system.

Quelle: Sciencedaily

Sleeper cells: Newly discovered stem cell resting phase could put brain tumors to sleep

Biomedical engineering researchers developed a new cell classifier tool that takes a higher-resolution look at the life cycle of neuroepithelial stem cells, which led to the discovery and exploration of a new resting phase called Neural G0. This knowledge could help scientists to better understand glioma brain tumors and develop new methods of treatment.

Quelle: Sciencedaily

Odds of stem cell transplant restoring fertility are as random as a coin toss — until now

The chances of restoring fertility through sperm stem cell transplant are as random as a coin toss. But a team of scientists developed a new strategy that serves as a ‚weighted coin‘ that can favorably rig the odds to achieve outcomes where fertility is successfully restored.

Quelle: Sciencedaily

Stem cell drugs surprise researchers: Could lead to better drugs in the future

Chemotherapy destroys stem cells, which then cannot develop into immune cells and become part of the body’s defenses. There are drugs that can remedy this, but previously we did not know exactly how these drugs worked. Now, a new study details their function providing new knowledge that may improve stem cell transplantation and lead to better drug design in the future.

Quelle: Sciencedaily

Bauchspeicheldrüsen-Tumore aus dem Labor: Organoide helfen, die Krebsentstehung zu verstehen

Für die Krebsforschung haben Ulmer Wissenschaftlerinnen und Wissenschaftler Bauchspeicheldrüsen-Organoide im Labor gezüchtet. Anhand dieser Modelle aus Stammzellen wollen die Forschenden die Entstehung von Bauchspeicheldrüsenkrebs nachvollziehen. Dadurch erhoffen sie sich neue, patientenspezifische Behandlungsansätze. Zudem könnten diese „duktalen Pankreas-Organoide“ dabei helfen, Tierversuche in der Krebsforschung zu reduzieren. Die aktuelle, in Kooperation mit dem Helmholtz Zentrum in München entstandene Publikation wurde im Journal „Cell Stem Cell“ veröffentlicht.

Quelle: IDW Informationsdienst Wissenschaft

Alzheimer-Modellierung zeigt überraschende Ergebnisse

Der Innsbrucker Molekularbiologe Jerome Mertens und sein Team modellierten erstmals auch die sporadische, nur im Alter auftretende Form von Alzheimer basierend auf Hautzellen von Patient*innen. Die in Cell Stem Cell veröffentlichten Ergebnisse belegen eine Altersabhängigkeit dieser Form der Krankheit und zeigen, dass Alzheimer-Nervenzellen und Krebszellen einiges gemeinsam haben.

Quelle: IDW Informationsdienst Wissenschaft

DKMS launches online platform for healthcare professionals

DKMS invites medical and healthcare professionals working in hematopoietic stem cell transplantation to visit the newly developed DKMS platform at www.professional.dkms.org. This website gives an overview of the work of all our specialist departments and offers comprehensive insights into the non-profit organization’s scientific studies and publications. Furthermore, it provides access to DKMS’ services, resources, grants and support programs. The site features a modern and streamlined design and makes it easy to access essential information.

Quelle: IDW Informationsdienst Wissenschaft

Wie Viren das wachsende Gehirn schädigen

Ein Forscherïnnenteam am IMBA – Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften – erforscht an sogenannten Organoiden, wie manche Viren schwere Fehlbildungen im menschlichen Gehirn auslösen können, mit dem Ziel neue Therapieansätze gegen Infektionen und deren Folgen zu entwickeln. Das berichtet das Team rund um Jürgen Knoblich aktuell im Fachmagazin Cell Stem Cell.

Quelle: IDW Informationsdienst Wissenschaft

Reactivating Aging Stem Cells in the Brain

As people get older, their neural stem cells lose the ability to proliferate and produce new neurons, leading to a decline in memory function. Researchers at the University of Zurich have now discovered a mechanism linked to stem cell aging – and how the production of neurons can be reactivated.

Quelle: IDW Informationsdienst Wissenschaft

Uncovering basic mechanisms of intestinal stem cell self-renewal and differentiation

The gut plays a central role in the regulation of the body’s metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach for diabetes therapy. For this, a detailed understanding of the intestinal stem cell lineage and the signals regulating the recruitment of intestinal cell types is critical.

Quelle: Sciencedaily

Reducing treatment-related complication for blood cancer patients

Researchers published promising findings on preventing a common complication to lifesaving blood stem cell transplantation in leukemia.

Quelle: Sciencedaily

Boosting stem cell activity can enhance immunotherapy benefits

Immune-system T cells have been reprogrammed into regenerative stem cell-like memory (TSCM) cells that are long-lived, highly active ’super immune cells‘ with strong antitumor activity, according to new research.

Quelle: Sciencedaily

New therapeutic approach against leukemia

Using an RNA molecule complex, researchers can prevent retention of cancer stem cell in their tumor supporting niche.

Quelle: Sciencedaily