Die Forschungsgruppe „Histologie“ am Forschungszentrum Borstel, Leibniz Lungenzentrum hat ein einfaches, aber aussagekräftiges Zellmuster im Bindegewebe rund um den Tumor identifiziert, das wichtige Hinweise auf das Langzeitüberleben von Patientinnen und Patienten mit nicht-kleinzelligem Lungenkarzinom (NSCLC) liefert. Quelle: IDW Informationsdienst Wissenschaft

TiHo researchers induce cell death in 3D mini-tumors and discover that forcing cancer cells to die can also alert the immune system and enhance anti-tumor attack. Quelle: IDW Informationsdienst Wissenschaft

TiHo-Forschende lösen in 3D-Minitumoren den Zelltod aus und finden heraus, dass das Erzwingen des Zelltods von Krebszellen auch das Immunsystem alarmieren und dessen Angriff auf den Tumor verstärken kann. Quelle: IDW Informationsdienst Wissenschaft

Understanding and controlling how cancer cells transition between different states remains a critical challenge in tumor biology. In a recent publication in Advanced Materials, researchers from the Leibniz Institute of Polymer Research Dresden (IPF) present a data-driven strategy to guide these transitions using engineered biomaterials. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Every human cell is surrounded by a sugar coating known as the glycocalyx. It not only interacts with its environment but also reveals a great deal about cells’ internal states. Scientists at the Max Planck Institute for the Science of Light (MPL) have mapped sugar structures on cell surfaces using high-resolution microscopy. In initial studies, they were able to correlate the spatial arrangement of the sugar structures with specific physiological cell states. The results, recently published in Nature Nanotechnology, could pave the way for new diagnostic approaches, such as tumor detection. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche…

• A medium consisting of growing and dividing cells drastically changes the behavior of other cells or particles trying to move through it • In such a medium, moving particles show clustering and phase separation even without specific attraction • The findings provide valuable insights for the dynamics of tumor growth, bacterial biofilms and synthetic micro-swimmers Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira Abstract Background The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients. Results Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover…

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline solid. However, living organisms are essentially isothermal. Because of very little differences in temperature between different parts of a cell it is assumed that energy flow in living organisms is mediated by differences in the turnover time of various metabolic processes in the cell, which occur in cyclical fashion. It has been shown that the cycle time of…

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination – still below heating threshold – may selectively target centrioles, impair mitosis and be a beneficial therapy against malignancy. If centrioles utilize quantum photons for entanglement, properties of centrosomes/centrioles approached more specifically could be useful for therapy. Healthy centrioles for a given organism or tissue differentiation should then have specific quantum optical properties detectable through some type of…

Susanne Rittinghausen, Anja Hackbarth, Otto Creutzenberg, Heinrich Ernst, Uwe Heinrich, Albrecht Leonhardt and Dirk Schaudien Abstract Background Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study. In the past, intraperitoneal carcinogenicity studies in rats using biopersistent granular dusts had always been negative, whereas a number of such studies with different asbestos fibers had shown tumor induction. The aim of this study was to identify possible carcinogenic effects of MWCNTs. We compared induced tumors with asbestos-induced mesotheliomas and evaluated their relevance for humans by immunohistochemical methods. Methods A total of 500…