Every human cell is surrounded by a sugar coating known as the glycocalyx. It not only interacts with its environment but also reveals a great deal about cells’ internal states. Scientists at the Max Planck Institute for the Science of Light (MPL) have mapped sugar structures on cell surfaces using high-resolution microscopy. In initial studies, they were able to correlate the spatial arrangement of the sugar structures with specific physiological cell states. The results, recently published in Nature Nanotechnology, could pave the way for new diagnostic approaches, such as tumor detection. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche…

• A medium consisting of growing and dividing cells drastically changes the behavior of other cells or particles trying to move through it • In such a medium, moving particles show clustering and phase separation even without specific attraction • The findings provide valuable insights for the dynamics of tumor growth, bacterial biofilms and synthetic micro-swimmers Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

• Multi-day gene activity profiles from the same cells • Long-term analysis of cell communication in mixed cultures • Potential applications in organoids and tumor microenvironments Until now, studying the genetic processes in cells required destroying them – making it impossible to observe these processes over extended periods of time. A team from the Technical University of Munich (TUM) and Helmholtz Munich has developed a new method to repeatedly obtain up-to-date genetic information from living cells. In the future, this will enable better monitoring of stem cells for therapies or the effects of drugs within cells. Quelle: IDW Informationsdienst Wissenschaft…

• Mehrtägige Genaktivitätsprofile aus denselben Zellen • Zellkommunikation in Mischkulturen erstmals langfristig analysierbar • Potenzial für Organoide und Tumor-Mikroumgebung-Studien Um die genetischen Vorgänge in Zellen untersuchen zu können, mussten diese dafür bislang zerstört werden. Das verhinderte die Beobachtung von Prozessen über längere Zeit hinweg. Ein Team der Technischen Universität München (TUM) und von Helmholtz Munich hat nun eine neue Methode entwickelt, um immer wieder aktuelle Geninformationen aus lebenden Zellen zu gewinnen. Dadurch lassen sich künftig zum Beispiel Stammzellen für Therapien oder die Wirkung von Medikamenten in Zellen besser kontrollieren. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Stem-cell memory T (TSCM) cells are able to self-renew, persist long term, and mount potent anti-tumor responses. These properties make them attractive for next-generation CAR T-cell therapies. However, their clinical potential has not previously been demonstrated in humans. A team of researchers co-led by Professor Luca Gattinoni from the Leibniz Institute for Immunotherapy (LIT) and Dr. James Kochenderfer from the National Cancer Institute has published a new study in Cell reporting, for the first time, that CAR T cells designed to acquire a TSCM phenotype demonstrate a favorable safety profile and can induce complete remissions at remarkably low doses without…

T-Stammgedächtniszellen (TSCM) erneuern sich selbst, überleben langfristig und können starke Anti-Tumor-Reaktionen erzeugen. Deshalb sind sie vielversprechende Kandidaten für CAR T Zelltherapien der nächsten Generation. Bisher fehlte der Nachweis für die Wirksamkeit beim Menschen. Ein Team unter Leitung von Prof. Luca Gattinoni vom Leibniz-Institut für Immuntherapie (LIT) und Dr. James Kochenderfer vom National Cancer Institute berichtet in der Fachzeitschrift Cell, dass CAR T Zellen mit TSCM Phänotyp in einer frühen klinischen Studie sicher und verträglich waren. Zudem bewirkten sie in niedrigen Dosen komplette Tumorrückbildungen – und das ohne eine chemotherapeutische Vorbehandlung. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen…

Professor Daniela Lössner and her research team—Dr. Ali Nadernezhad, Dr. Sandra Hauser, and Dr. Verena Kast—have been presented with the 2025 Innovation Award by the Association of Supporters of the Leibniz Institute of Polymer Research Dresden (IPF). The award recognizes their use of biomaterials to model the tumor microenvironment. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Der desmoplastische klein- und rundzellige Tumor ist selten, aggressiv und schwer zu behandeln. Forschende am Nationalen Centrum für Tumorerkrankungen (NCT) Heidelberg und am Deutschen Krebsforschungszentrum (DKFZ) haben 30 Tumoren umfassend analysiert und für fast alle Betroffenen potenzielle personalisierte Therapieoptionen abgeleitet. Bei einzelnen Patientinnen und Patienten konnten neue zielgerichtete Ansätze die Krankheit überraschend lange aufhalten. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Research team at OncoRay identifies MMP11 as a promising biomarker for liquid biopsy in prostate cancer Metastatic prostate cancer is currently associated with high morbidity and mortality rates. In addition, patients respond very differently to standard treatments such as hormone therapy or radiation therapy. Reliable markers that can be used to predict aggressive tumor progression and treatment success at an early stage are still largely lacking. A research team led by Prof. Anna Dubrovska and Dr. Ielizaveta Gorodetska from OncoRay – National Center for Radiation Research in Oncology has now identified a biomarker that can be measured in the blood….

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira Abstract Background The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients. Results Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover…

Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation  in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline solid. However, living organisms are essentially isothermal. Because of very little differences in temperature between different parts of a cell it is assumed that energy flow in living organisms is mediated by differences in the turnover time of various metabolic processes in the cell, which occur in cyclical fashion. It has been shown that the cycle time of…

Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination – still below heating threshold – may selectively target centrioles, impair mitosis and be a beneficial therapy against malignancy. If centrioles utilize quantum photons for entanglement, properties of centrosomes/centrioles approached more specifically could be useful for therapy. Healthy centrioles for a given organism or tissue differentiation should then have specific quantum optical properties detectable through some type of…

Susanne Rittinghausen, Anja Hackbarth, Otto Creutzenberg, Heinrich Ernst, Uwe Heinrich, Albrecht Leonhardt and Dirk Schaudien Abstract Background Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study. In the past, intraperitoneal carcinogenicity studies in rats using biopersistent granular dusts had always been negative, whereas a number of such studies with different asbestos fibers had shown tumor induction. The aim of this study was to identify possible carcinogenic effects of MWCNTs. We compared induced tumors with asbestos-induced mesotheliomas and evaluated their relevance for humans by immunohistochemical methods. Methods A total of 500…