Researchers Find NTRK fusions more common than expected in pediatric tumors

Researchers have found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors.

Quelle: Sciencedaily

An unexpected, and novel, target for prostate cancer: Our biological clock

Researchers find that CRY-1, a regulator of circadian rhythms, promotes tumor progression by altering DNA repair.

Quelle: Sciencedaily

The role of T cells in fighting cancer

Why do some hosts‘ immune systems reject tumors easily, while others have a harder time doing so? It depends on the types of the immune cells known as CD8 T cells and how a host’s specific T cells match up with the neoantigens present in the tumor.

Quelle: Sciencedaily

Even skin shielded from the sun accumulates genomic DNA changes from UV light

For the first time, scientists have measured the different types of genomic DNA changes that occur in skin cells, finding that mutations from ultraviolet (UV) light is especially common, but Black individuals have lower levels of UV damage compared to white people.

Quelle: Sciencedaily

Researchers discover new inhibitor drug combination for rare form of cancer

Researchers took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that were effective in reducing the growth of the Waldenström macroglobulinemia cancer cells and when combined with a third drug were even more successful in killing the WM cancer cells which could lead to more treatment options.

Quelle: Sciencedaily

Reverse engineering 3D chromosome models for individual cells

A new computational technique that uses heat map data to reverse engineer highly detailed models of chromosomes and researchers have uncovered new information about the close spatial relationships that chromatin folding creates between genes.

Quelle: Sciencedaily

Cancer models created by mechanical engineers offer new insight into tumor growth

Engineers have developed in vitro — in the lab — lymphatic vessel model to study the growth of tumor emboli, collections of tumor cells within vessels that are often associated with increased metastasis and tumor recurrence.

Quelle: Sciencedaily

Biochemical pathway that protects cells from ferroptosis discovered

In an article published in Cell Metabolism, Moffitt Cancer Center researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis.

Quelle: Sciencedaily

Study demonstrates efficacy of new treatment for neurofibromatosis type 1-related tumors

Based on preclinical studies of an investigational drug to treat peripheral nerve tumors, researchers have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1).

Quelle: Sciencedaily

Cancer research reveals how mutations in a specific gene cause different types of disease

Leading cancer expert solve long-standing question of how various types of mutations in just one gene cause different types of diseases.

Quelle: Sciencedaily

New insights into the control of inflammation

Scientists discovered that EGR1inhibits expression of pro-inflammatory genes in macrophages. The discovery expands the understanding of how macrophages are set off and deactivated in the inflammatory process, which is critical in many normal and pathological conditions.

Quelle: Sciencedaily

The cancer microbiome reveals which bacteria live in tumors

Biomedical engineers have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA). With a clearer picture of the microbiota living in various organs in both healthy and cancerous states, researchers will now be able to find new biomarkers of disease and better understand how numerous cancers affect the human body.

Quelle: Sciencedaily

Scientists find antibody that blocks dengue virus

A research team confirm an effective antibody that prevents the dengue virus from infecting cells in mice, and may lead to treatments for this and similar diseases.

Quelle: Sciencedaily

Understanding how to improve antibodies targeting OX40 for the treatment of cancer

Scientists have gained new insight into how the immune system can be better used to find and kill cancer cells.

Quelle: Sciencedaily

Killing cancer by unleashing the body’s own immune system

The body’s immune system is the first line of defense against infections like bacteria, viruses or cancers. Some cancers, however, have developed the art of molecular deception to avoid destruction by the body’s immune system. Now, a researcher might have found a new way to help the body’s immune system get past that deception and destroy the cancer.

Quelle: Sciencedaily

Scientists develop method to more efficiently isolate and identify rare T cells

Scientists have developed a technique that will enable researchers to more efficiently isolate and identify rare T cells that are capable of targeting viruses, cancer and other diseases.

Quelle: Sciencedaily

New humanized mouse model provides insight into immunotherapy resistance

Scientists have created an advanced humanized immune system mouse model that allows them to examine resistance to immune checkpoint blockade therapies in melanoma. It has revealed a central role for mast cells.

Quelle: Sciencedaily

Higher coffee intake may be linked to lower prostate cancer risk

Drinking several cups of coffee every day may be linked to a lower risk of developing prostate cancer, suggests a pooled data analysis of the available evidence.

Quelle: Sciencedaily

One in five brain cancers fueled by overactive mitochondria

A new study has found that up to 20% of aggressive brain cancers are fueled by overactive mitochondria and new drugs in development may be able to starve the cancers.

Quelle: Sciencedaily

Cracking the code of a shapeshifting protein

A shapeshifting immune system protein called XCL1 evolved from a single-shape ancestor hundreds of millions of years ago. Now, researchers have discovered the molecular basis for how this happened. In the process they uncovered principles that scientists can use to design purpose-built nanoscale transformers for use as biosensors, components of molecular machines, and even therapeutics.

Quelle: Sciencedaily

New evidence of health threat from chemicals in marijuana and tobacco smoke

Scientists have uncovered new evidence of the potential health risks of chemicals in tobacco and marijuana smoke.

Quelle: Sciencedaily

Uncovering basic mechanisms of intestinal stem cell self-renewal and differentiation

The gut plays a central role in the regulation of the body’s metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach for diabetes therapy. For this, a detailed understanding of the intestinal stem cell lineage and the signals regulating the recruitment of intestinal cell types is critical.

Quelle: Sciencedaily

Study identifies exposure to common food-borne pathogen linked to rare brain cancer

A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults.

Quelle: Sciencedaily

Novel RNA factors may help cancer cells thrive

Recent work pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome.

Quelle: Sciencedaily

Single-dose COVID-19 vaccine triggers antibody response in mice

Researchers have developed a nanoparticle vaccine that elicits a virus-neutralizing antibody response in mice after only a single dose.

Quelle: Sciencedaily