Researchers have discovered that a key protein, cFLIP, is essential for regulating programmed cell death in lymphoma cells. This discovery provides insights into the mechanisms of this cancer’s cell death evasion and could open up new therapeutic routes for patients who do not respond to therapies / publication in “Blood” Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Forschende der Universität zu Köln zeigen, dass das Schlüsselprotein cFLIP für die Regulierung des programmierten Zelltods in Lymphomzellen entscheidend ist. Sie geben Einblicke in die Mechanismen, mit denen diese Krebsart den Zelltod umgeht. Das Ergebnis könnte neue Therapiemöglichkeiten für Patient*innen eröffnen, die auf bisherige Behandlungsoptionen nicht ansprechen / Veröffentlichung in „Blood“ Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

In einer Studie der Universitätsmedizin Mainz konnten Krebszellen bei akuter myeloischer Leukämie durch einen neu entdeckten Mechanismus gezielt geschwächt werden. Die Hemmung bestimmter Proteine, die die Genaktivität beeinflussen, löste eine starke Abwehrreaktion der Krebszellen aus. Diese Immunantwort ähnelte der einer Grippe, schwächte die Tumorzellen und konnte deren Zelltod auslösen. Mit immunstimulierenden Botenstoffen konnten die Forschenden diesen Effekt sogar verstärken. Langfristig könnten die Ergebnisse dazu beitragen, eine neue, gezielt entwickelte Kombinationstherapie für akute myeloische Leukämie zu entwickeln. Die Ergebnisse wurden in der Fachzeitschrift Blood veröffentlicht. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Researchers showed that the level of synaptic impairment seen in stem cell-derived neurons of schizophrenia patients, generated from blood samples, predicted their level of cognitive impairment. This is the first time that researchers could show an intraindividual mechanistic explanation for the individual degree of schizophrenia’s cognitive symptoms. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

High-risk patients with acute pulmonary embolism can benefit from targeted ultrasound-facilitated, catheter-directed therapy, as demonstrated by a large international clinical study under the scientific leadership of the University Medical Center Mainz. The researchers investigated the efficacy of a minimally invasive procedure in which a thrombolytic (blood clot-dissolving) drug is administered directly into the pulmonary arteries via a special catheter while the clot is simultaneously treated with ultrasound energy. Compared to the previous standard therapy using blood-thinning medications only, mortality or life-threatening circulatory collapse was 61 percent lower. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

Die DKMS ehrt herausragende Forschungsleistungen und fördert junge Wissenschaftler:innen im Bereich der Stammzelltransplantation und Zelltherapie für hämatologische Erkrankungen bei der Jahrestagung der European Society for Blood and Marrow Transplantation (EBMT) in Madrid. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

DKMS recognizes outstanding research and supports young scientists in the field of stem cell transplantation and cell therapy for hematological diseases at the conference of the European Society For Blood And Marrow Transplantation (EBMT) in Madrid. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …

A certain blood protein regarded as an early indicator of Alzheimer’s disease also appears to play a role in other disorders. Researchers at DZNE and the Hertie Institute for Clinical Brain Research (HIH) at the University of Tübingen have found that elevated levels of phosphorylated tau protein (pTau) also occur in two lesser-known conditions that primarily affect the heart and kidneys. These findings open up new perspectives for improved diagnostics and were published this week in the journal “Nature Medicine”. They are based on data from 280 older individuals from Germany, Italy, and the Netherlands. Quelle: IDW Informationsdienst Wissenschaft

Research team at OncoRay identifies MMP11 as a promising biomarker for liquid biopsy in prostate cancer Metastatic prostate cancer is currently associated with high morbidity and mortality rates. In addition, patients respond very differently to standard treatments such as hormone therapy or radiation therapy. Reliable markers that can be used to predict aggressive tumor progression and treatment success at an early stage are still largely lacking. A research team led by Prof. Anna Dubrovska and Dr. Ielizaveta Gorodetska from OncoRay – National Center for Radiation Research in Oncology has now identified a biomarker that can be measured in the blood….

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira Abstract Background The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients. Results Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover…

Susanne Rittinghausen, Anja Hackbarth, Otto Creutzenberg, Heinrich Ernst, Uwe Heinrich, Albrecht Leonhardt and Dirk Schaudien Abstract Background Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study. In the past, intraperitoneal carcinogenicity studies in rats using biopersistent granular dusts had always been negative, whereas a number of such studies with different asbestos fibers had shown tumor induction. The aim of this study was to identify possible carcinogenic effects of MWCNTs. We compared induced tumors with asbestos-induced mesotheliomas and evaluated their relevance for humans by immunohistochemical methods. Methods A total of 500…