Benefit of risk-based breast cancer screening is still unclear

The Austrian Institute for Health Technology Assessment (AIHTA) has analysed whether risk-based breast cancer screening has advantages over the conventional age-based screening programme. The central result: the current prediction models cannot satisfactorily predict the individual breast cancer risk. Only large studies which are currently in progress will provide robust data on whether women can expect health advantages compared to conventional practice. „In any case, such a system needs extensive preparation. Simply assessing risk factors in women without thinking about further consequences has no benefit for women,“ emphasises Ingrid Zechmeister-Koss, deputy director of the AIHTA.

Quelle: IDW Informationsdienst Wissenschaft

Half of all women experience false positive mammograms after 10 years of annual screening

Half of all women experience a false positive mammogram after 10 years of annual breast cancer screening with 3D mammography, a UC Davis-led study estimates. This risk was lower for women who had mammograms every other year. 3D screening showed slightly lower false positive results than standard mammography.

Quelle: Sciencedaily

Molecular networks could explain racial disparity in triple negative breast cancer deaths

Different activity in two molecular networks could help explain why triple negative breast cancers tend to be more aggressive in African American (AA) women compared with white American (WA) women, a new study suggests.

Quelle: Sciencedaily

MRI may lower breast cancer deaths from variants in 3 genes

Annual MRI screenings starting at ages 30 to 35 may reduce breast-cancer mortality by more than 50% among women who carry certain genetic changes in three genes, according to a comparative modeling analysis. The predictions involve pathogenic variants in ATM, CHEK2 and PALB2 genes — which collectively are as prevalent as the much-reported BRCA1/2 gene mutations.

Quelle: Sciencedaily

Pandemic upends breast cancer diagnoses

Researchers surveyed and compared early- and late-stage breast and colorectal cancer diagnoses in patients in pre-pandemic 2019 and in 2020, the first full year of the COVID-19 pandemic, discovering fewer of the former and more of the latter as patients delayed care.

Quelle: Sciencedaily

New path to treat advanced triple-negative breast cancer

A new study shows inhibition of the CECR2 gene prevents triple-negative breast cancer from advancing or metastasizing.

Quelle: Sciencedaily

Researchers discover new way to target secondary breast cancer that has spread to the brain

A study has revealed a potential new way to treat secondary breast cancer that has spread to the brain, using existing drugs.

Quelle: Sciencedaily

Live cells discovered in human breast milk could aid breast cancer research

Researchers have explored the cellular changes that occur in human mammary tissue in lactating and non-lactating women, offering insight into the relationship between pregnancy, lactation, and breast cancer.

Quelle: Sciencedaily

Players needed to solve puzzles and help advance cancer research

Scientists have just launched GENIGMA, a videogame that enlists players to solve puzzles while generating real-world scientific data that can detect alterations in genomic sequences and ultimately advance breast cancer research. The game was created to boost worldwide research efforts that depend on cancer cell lines, a critical resource used by scientists to study cancer and test new drugs to treat the disease. One of the limitations of cancer cell lines are a lack of high-resolution genome reference maps, which are necessary to help researchers interpret their scientific results.

Quelle: Sciencedaily

Faulty BRCA genes linked to prostate and pancreatic cancers

Faulty versions of the BRCA1 and BRCA2 genes are well known to increase the risk of breast cancer in men and women, and in ovarian cancer. Now BRCA1 and BRCA2 have been linked to several other cancers, including those that affect men.

Quelle: Sciencedaily

The first AI breast cancer sleuth that shows its work

Researchers have developed an artificial intelligence platform to analyze potentially cancerous lesions in mammography scans to determine if a patient should receive an invasive biopsy. But unlike its many predecessors, the algorithm is interpretable, meaning it shows physicians exactly how it came to its conclusions.

Quelle: Sciencedaily

Researchers reduce breast cancer metastasis in animal models by modifying tumor electrical properties

Researchers have found that manipulating voltage patterns of tumor cells — using ion channel blockers already FDA-approved as treatments for other diseases — can in fact significantly reduce metastasis in animal models of breast cancer.

Quelle: Sciencedaily

Reducing copper in the body alters cancer metabolism to reduce risk of aggressive breast cancer

Depleting copper levels may reduce the production of energy that cancer cells need to travel and establish themselves in other parts of the body by a process referred to as metastasis, according to a new study. The discovery of the underlying mechanisms of how copper depletion may help reduce metastasis in breast cancer will help inform the design of future clinical trials.

Quelle: Sciencedaily

Cancer-spotting AI and human experts can be fooled by image-tampering attacks

Artificial intelligence (AI) models that evaluate medical images have potential to speed up and improve accuracy of cancer diagnoses, but they may also be vulnerable to cyberattacks. Researchers simulated an attack that falsified mammogram images, fooling both an AI breast cancer diagnosis model and human breast imaging radiologist experts.

Quelle: Sciencedaily

Chemo helps breast cancer cells get their ‘foot in the door’ to the lungs

A new study adds to the evidence that chemotherapy enhances cancer’s spread beyond the primary tumor, showing how one chemo drug allows breast cancer cells to squeeze through and attach to blood vessel linings in the lungs.

Quelle: Sciencedaily

Metabolic memory plays a key role in breast cancer relapse

Molecular targets for therapies that could prevent breast cancer recurrence have been identified by a group of scientists who analyzed tumor cells that proved resistant to the original treatment. Recent advances in early detection and targeted therapy have led to a growing success in treating breast cancer upon first presentation. This often is achieved by silencing tumor driving oncogenes and causing tumor regression.

Quelle: Sciencedaily

Guidance on supplemental breast cancer screening for women with dense breast tissue

Researchers have made recommendations for clinicians and patients regarding supplemental screening for women with dense breast tissue.

Quelle: Sciencedaily

Starting mammography at age 40 would reduce disparities in deaths for Black women

If Black women begin mammography screening every other year starting at age 40, breast cancer deaths could be reduced by 57 percent compared to starting screening 10 years later according to recent analyses.

Quelle: Sciencedaily

Prediction models may reduce false-positives in MRI breast cancer screening

Prediction models based on clinical characteristics and imaging findings may help reduce the false-positive rate in women with dense breasts who undergo supplemental breast cancer screening with MRI, according to a new study.

Quelle: Sciencedaily

Researchers solve structure of BRCA2 protein complex important in DNA repair

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The breakdown of this interaction is a hallmark of many cancers. Now scientists have determined the structure of a complex of two proteins — BRCA2 together with MEILB2 — that allows repairs to happen efficiently in cells undergoing cell-splitting, called meiosis. Their results have major implications for cancer and infertility.

Quelle: Sciencedaily

Changes in lung tissue indicate preparation for supporting the growth of disseminated breast cancer cells

A new study has revealed changes in healthy lung tissue which indicate preparation to receive metastases. The changes were identified in the area known as ‚the micro-environment‘ of the tumor, and specifically in connective tissue known as fibroblasts.

Quelle: Sciencedaily

Statins may improve survival for triple-negative breast cancer patients

A new study found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.

Quelle: Sciencedaily

Seeking a unique treatment for lobular breast cancer

In an attempt to find out why the long-term outcomes are poorer for patients with lobular breast cancer — which affects some 40,000 women a year — researchers began looking at the role of the protein MDC1 in tumor cells.

Quelle: Sciencedaily

Maternal diets rich in Omega-3 fatty acids may protect offspring from breast cancer, study suggests

Researchers noted a significant difference in mice from mothers that were fed a diet rich in canola oil, compared with mothers fed a diet rich in corn oil. A maternal Omega 3-rich diet affected genome-wide epigenetic landscape changes in offspring and potentially modulated gene expression patterns.

Quelle: Sciencedaily

Cholesterol metabolite induces production of cancer-promoting vesicles

Scientists studying the link between cholesterol and breast cancer report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles.

Quelle: Sciencedaily