A research group has analyzed how certain immune cells known as innate lymphoid cells (ILCs) develop into mature cells that play a part in inflammatory bowel disease (IBD). The findings could pave the way for more effective treatments against IBD, a disease that causes considerable suffering and that is linked to an increased risk of colorectal cancer.
Researchers undertook a systematic analysis of the molecular building blocks used to engineer therapeutic cells. Their work resulted in a comprehensive rule book for the design of therapeutic cells with improved specificity and safety, and for the eventual customization of cell-based therapies.
A study examined the differences in intratumoral immune responses between male and female cancers of non-reproductive origin.
Melanoma is a somewhat unusual cancer — one that blooms before our very eyes, often on sun-exposed skin, and can quickly become deadly as it turns our own skin against us and spreads to other organs. Fortunately, when caught early, melanoma can often be cured by simple surgery, and there are now better treatments for advanced cases, including immunotherapies that prime a patient’s immune system to fight off the cancer. However, much remains unknown about melanoma, including the details of how it develops in the earliest stages, and how to best identify and treat the most dangerous early cases. Spatial maps of melanoma reveal how individual cells interact as cancer progresses.
Researchers want to improve their understanding of the immune environment in ovarian cancer in hopes of making immunotherapy an option for these patients. Researchers now report on key characteristics of immune cells in ovarian cancer and identify cell types important for mediating an immune response.
Using retrospective clinical data and in-depth lab studies, researchers have discovered that vitamin E can enhance immunotherapy responses by stimulating dendritic cells in the tumor.
Researchers have found a way to supercharge immune cells that could enable them to clear disease and infections faster
In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers describe the mechanisms that modify the structure of T lymphocytes and hinder their migration towards the tumors to be destroyed. This discovery provides new perspectives on the migration of immune cells, a key process in antitumor immune defense.
Researchers have devised an immunotherapy technique that combines chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, with a cancer-killing virus to more effectively target and treat solid cancer tumors.
Cancer cells can disrupt a metabolic pathway that breaks down fats and proteins to boost the levels of a byproduct called methylmalonic acid, thereby driving metastasis, according to new research. The findings open a new lead for understanding how tumors metastasize, or spread to other tissues, and hints at novel ways to block the spread of cancer by targeting the process.
Scientists have created a new roadmap that traces each step in the development of blood stem cells in the human embryo, providing scientists with a blueprint for producing fully functional blood stem cells in the lab. The research could help expand treatment options for blood cancers like leukemia and inherited blood disorders such as sickle cell disease.
A new study suggests that people with cancer and non-O blood types, such as types A, B, and AB, face an increased risk of developing venous thromboembolism (VTE), or blood clots in the veins, three months after their initial diagnosis. Scientists have long strived to understand the risk factors for VTE, the leading cause of preventable hospital deaths in the United States. Existing assessments use factors like tumor or cancer type to detect those at high risk of VTE. Yet, many patients without these diagnoses still develop life-threatening blood clots but go unidentified.
Cellular biologists discover why some patients become resistant to standard treatments for nonsmall cell lung cancer.
Researchers have developed a new computational tool to select optimal combination therapies for patients with cancer based on the co-occurring alterations in a given tumor.
Researchers have developed a novel substance that disables a protein in the cell skeleton, leading to cell death. In this way, substances of this type can prevent, for example, the growth of tumors. To accomplish this, the researchers combined a structural biological method with the computational design of active agents.
Researchers have developed a 3D printing technique to fabricate microfluidic devices for biomedical applications at a microscale not previously possible.
For cancer patients, COVID-19 poses a particular risk due to their often compromised immune systems. Now, a study shows that, due to Omicron, there is an increasing number of breakthrough infections in people with cancer, especially while they are undergoing cancer therapy.
Biological engineers have devised a new experimental tool that allows them to precisely pick out interactions between a particular B or T cell and its target antigen.
Cigarette smoking is overwhelmingly the main cause of lung cancer, yet only a minority of smokers develop the disease. A study suggests that some smokers may have robust mechanisms that protect them from lung cancer by limiting mutations. The findings could help identify those smokers who face an increased risk for the disease and therefore warrant especially close monitoring.
An international study demonstrates that the body’s immune system attacks itself in a rare type of blood cancer. Consequently, treatment should be targeted at the immune system as well, not only the cancer cells.
Bacteria promote cancer metastasis by bolstering the strength of host cells against mechanical stress in the bloodstream, promoting cell survival during tumor progression, researchers report.
Chromosomal abnormalities are found in most multiple myeloma (MM) patients. While myeloma patients have generally benefited from the advancement of treatment modalities over the years, the treatment outcome for patients having two or more high-risk prognostic events remains poor. In a novel step forward, a research team has embarked on a study which aims to address the unmet clinical need in this group of patients.
Experts have identified for the first time exactly how exercise can lower your risk of getting bowel cancer and slow the growth of tumors.
Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, scientists report. The findings could lead to new ways of manipulating STING to prompt stronger immune responses or stem its action in autoimmune diseases.
A research review into molecular insights of a licorice-derived substance called glycyrrhizin for preventing or treating cancer suggests further research could lead to specific agents for clinical use.