Design of protein binders from target structure alone

Scientists have now created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin receptor, as well as vulnerable proteins on the surface of viruses. This solves a long-standing challenge in drug development and may lead to new treatments for cancer, diabetes, infection, inflammation, and beyond.

Quelle: Sciencedaily

New pathway for DNA transfer discovered in tumor microenvironment

Researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.

Quelle: Sciencedaily

Corona in Deutschland: Sieben-Tage-Inzidenz steigt leicht auf 1758,4

Das Robert Koch-Institut hat 252.026 Corona-Neuinfektionen registriert. Die Sieben-Tage-Inzidenz hat sich demnach minimal erhöht. Binnen 24 Stunden sind 278 weitere Menschen im Zusammenhang mit dem Virus gestorben.

Quelle: SPIEGEL ONLINE

Study shows how bioactive substance inhibits important receptor

The A2A receptor regulates how vigorously the innate immune system attacks diseased cells. Researchers have now been able to show for the first time how an important inhibitor binds to the receptor. In the future, the results will facilitate the targeted search for molecules that give the innate immune system more punch. These could for instance be used in the fight against cancer, but also against brain diseases such as Alzheimer’s or Parkinson’s disease.

Quelle: Sciencedaily

Half of all women experience false positive mammograms after 10 years of annual screening

Half of all women experience a false positive mammogram after 10 years of annual breast cancer screening with 3D mammography, a UC Davis-led study estimates. This risk was lower for women who had mammograms every other year. 3D screening showed slightly lower false positive results than standard mammography.

Quelle: Sciencedaily

Spinal fluid sampling used to track treatment response in pediatric glioma

Treatment for glioma has long relied on MRI imaging to track tumor markers and treatment response. But new findings suggest a new method could provide additional data about tumor markers before changes appear on an MRI, indicating possible strategies to help clinicians address this aggressive form of cancer.

Quelle: Sciencedaily

Novel method to identify and treat aggressive early-stage lung cancers

Researchers have developed a novel method to identify aggressive early-stage lung cancers and target drugs known as aurora kinase inhibitors to tumors that are especially likely to respond to them. The findings could lead to great advances in treatment for lung adenocarcinoma, the most common type of lung cancer.

Quelle: Sciencedaily

Coronavirus in Afrika: Wie viele Afrikaner sind wirklich an Corona gestorben?

Corona, so wird oft behauptet, verläuft glimpflich in den jungen Gesellschaften Afrikas. Forscher haben nun in Sambia Tote untersucht – und sehr viele Coronaviren gefunden.

Quelle: SPIEGEL ONLINE

Coronavirus: Omikron kann bei Kindern schweren Pseudokrupp auslösen

Eine Coronainfektion verläuft bei Kindern meist mild. Doch in Einzelfällen kann die Omikron-Variante Pseudokrupp-Anfälle auslösen.

Quelle: SPIEGEL ONLINE

Coronavirus: Paul-Ehrlich-Institut hält Antigentests auch bei Omikron für zuverlässig

Einzelne Studien geben Hinweise darauf, dass Schnelltests bei Omikron nicht so gut anschlagen wie bei vorherigen Varianten. Das PEI hat einige Tests nun überprüft – und widerspricht dieser Einschätzung.

Quelle: SPIEGEL ONLINE

Corona in Deutschland: RKI meldet 296.498 Neuinfektionen – Inzidenz steigt weiter

Erstmals wurden dem Robert Koch-Institut binnen einer Woche mehr als 1,5 Millionen Infektionen mit dem Coronavirus gemeldet. Zuletzt stieg auch die Sieben-Tage-Inzidenz erneut leicht an.

Quelle: SPIEGEL ONLINE

Study suggests association between consuming artificial sweeteners and increased cancer risk

Artificial sweeteners reduce added sugar content and corresponding calories while maintaining sweetness. A new study suggests that some artificial sweeteners are associated with increased cancer risk.

Quelle: Sciencedaily

Tuberculosis induces premature cellular aging

Researchers found that the cells of humans and animals who have recovered from tuberculosis had prematurely aged up to 12 to 14 years. It’s possible that this premature cellular aging is one reason why survivors of tuberculosis have a high risk of mortality.

Quelle: Sciencedaily

In animal study, implant churns out CAR-T cells to combat cancer

Researchers have developed an implantable biotechnology that produces and releases CAR-T cells for attacking cancerous tumors. In a proof-of-concept study involving lymphoma in mice, the researchers found that treatment with the implants was faster and more effective than conventional CAR-T cell cancer treatment.

Quelle: Sciencedaily

RKI: Erstmals mehr als 1,5 Millionen Corona-Fälle in einer Woche

Neuer Rekord für Deutschland: Laut dem Robert Koch-Institut haben sich in der vergangenen Woche so viele Menschen mit Covid-19 angesteckt wie nie zuvor. Besonders betroffen: 75- bis 79-Jährige.

Quelle: SPIEGEL ONLINE

Corona in Deutschland: RKI registriert erstmals mehr als 300.000 Neuinfektionen

Der Trend zu steigenden Coronakennzahlen setzt sich fort. Aktuell registrierte das Robert Koch-Institut 300 weitere Virustodesopfer binnen 24 Stunden.

Quelle: SPIEGEL ONLINE

Novel therapeutic strategy shows promise against pancreatic cancer

Pancreatic cancer is notoriously difficult to cure or even treat. Now, a new strategy has succeeded in making pancreatic tumors visible to the immune systems of mice and vulnerable to immune attack, reducing cancer metastases by 87%.

Quelle: Sciencedaily

FDA approved new immunotherapy regimen for patients with melanoma

The U.S. Food and Drug Administration has approved a novel therapy for patients with metastatic or inoperable melanoma, an aggressive type of skin cancer.

Quelle: Sciencedaily

Coronavirus: Moderna-Impfstoff auch bei ganz kleinen Kindern sicher

Bisher ist noch kein Coronaimpfstoff für Kinder unter fünf Jahren zugelassen. Der Hersteller Moderna vermeldet nun positive Studienergebnisse: Die zweimalige Gabe des Präparats ruft demnach robuste Antikörper-Spiegel hervor.

Quelle: SPIEGEL ONLINE

Die Gedanken eines Eingeschlossenen

Zwei solcher Mikroelektroden-Panels, jedes 3,2 Quadratmillimeter groß, wurden zum Ableiten der Hirnsignale in die Großhirnrinde verpflanzt.

Ein junger schwerkranker Mann ist verstummt. Gefangen in seinem eigenen Körper. Dann lernt er, durch Drähte im Hirn zu sprechen. Eine Sensation der Neurotechnik und ein deutsches Forscherdrama.

Quelle: FAZ.NET

Getting fuel to an invading cell’s front line

Invading armies need a steady supply of fuel and armaments. That’s just as true when the invaders are cells, such as when tumor cells break away and spread to other parts of the body in a process called metastasis — the most deadly part of cancer. Now, a study in C. elegans worms provides new insight into how invading cells deploy fuel to the front lines of invasion to power their break-through machinery.

Quelle: Sciencedaily

Nanoparticle-based COVID-19 vaccine could target future infectious diseases

Just one dose of a new nanoparticle-based COVID-19 vaccine was enough to produce an immune response in animals on track with vaccines currently in clinical use. And with minor changes, researchers hope the same vaccine platform could target other infectious diseases.

Quelle: Sciencedaily

Chronologically young, biologically old: DNA linked to cancer survivors premature aging

Scientists have identified variants in two genes that are associated with accelerated aging in childhood cancer survivors.

Quelle: Sciencedaily

Could diet modification make chemotherapy drugs more effective for patients with pancreatic cancer?

The findings of a new study suggest that a ketogenic diet — which is low in carbohydrates and protein, but high in fat — helps to kill pancreatic cancer cells when combined with a triple-drug therapy. In laboratory experiments, the ketogenic diet decreased glucose (sugar) levels in the tumor, suggesting the diet helped starve the cancer. In addition, this diet elevated ketone bodies produced by the liver, which put additional stress on the cancer cells.

Quelle: Sciencedaily

Researchers use ultrasound to predict ovarian cancer

The appearance of ovarian lesions on ultrasound is an effective predictor of cancer risk that can help women avoid unnecessary surgery, according to a new study.

Quelle: Sciencedaily