Living donation opens new doors for colorectal cancer patients in need of liver transplants

A study is the first in North America to demonstrate that living-donor liver transplant is a viable option for patients who have systemically controlled colorectal cancer and liver tumors that cannot be surgically removed.

Quelle: Sciencedaily

Hands, feet, and fins: The connection that explains acral melanoma

Scientists are using zebrafish to understand human skin cancer that attacks the hands and feet.

Quelle: Sciencedaily

Hands, feet, and fins: The connection that explains acral melanoma

Scientists are using zebrafish to understand human skin cancer that attacks the hands and feet.

Quelle: Sciencedaily

Anti-cancer dream cream shrinks oral tumors

Researchers have found that treatment with miR-634 reduces the resistance of oral squamous cell carcinoma cells to cisplatin, resulting in increased tumor cell killing. An ointment containing miR-634 had a similar effect in mice, suggesting that this simple topical treatment could be used to improve the prognosis of patients with advanced oral cancer.

Quelle: Sciencedaily

Anti-cancer dream cream shrinks oral tumors

Researchers have found that treatment with miR-634 reduces the resistance of oral squamous cell carcinoma cells to cisplatin, resulting in increased tumor cell killing. An ointment containing miR-634 had a similar effect in mice, suggesting that this simple topical treatment could be used to improve the prognosis of patients with advanced oral cancer.

Quelle: Sciencedaily

Study shows critical protein may play a role in origin of mesothelioma

Researchers have discovered that a protein critical in the embryonic stages of life is reactivated in certain cases of mesothelioma, offering clues into the origin of this aggressive cancer.

Quelle: Sciencedaily

New algorithm will improve bowel-cancer patient care

An algorithm which can predict how long a patient might spend in hospital if they’re diagnosed with bowel cancer could save the money and help patients feel better prepared.

Quelle: Sciencedaily

Curevac: Klinische Studie für Corona-Impfstoff der zweiten Generation gestartet

Das Tübinger Unternehmen Curevac entwickelt einen neuen Coronaimpfstoff, der mehrere Virusvarianten zugleich erledigen soll. Nun wurde der erste Proband geimpft. Studienergebnisse sollen im zweiten Halbjahr vorliegen.

Quelle: SPIEGEL ONLINE

Schnelltests mangelhaft? Virologe kritisiert Schnellteststudie des Paul-Ehrlich-Instituts

Das Paul-Ehrlich-Institut hat vielen Antigenschnelltests ein gutes Zeugnis beim Omikron-Nachweis ausgestellt. Zu Unrecht, meint der Münchner Virologe Oliver Keppler, die Studie sei unzulänglich. Kritik gibt es vor allem an der Stichprobe.

Quelle: SPIEGEL ONLINE

Diabetes-Welle ein Jahr später: Nach Corona der Zuckerschock

Messung des Blutzuckerspiegels in Blutstropfen.

Die Gefahr eines Diabetesleidens kann lange nach einer Covid-19-Infektion offenbar deutlich erhöht sein – selbst bei milden Verläufen. Eine deutsche und eine US-Studie suchen die Risikofaktoren und vergrößern die Long-Covid-Sorgen.

Quelle: FAZ.NET

Researchers identify key complex for ribosome generation

Researchers have identified a four-protein complex that appears to play a key role in generating ribosomes — organelles that serve as protein factories for cells — as well as a surprising part in neurodevelopmental disorders. The findings could lead to new ways to manipulate ribosome production, which could impact a variety of conditions that affect human health.

Quelle: Sciencedaily

Study finds 10-second videos predict blood cancer relapse

Ten-second videos of white blood cell motion in the skin’s microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.

Quelle: Sciencedaily

How accelerated biological aging may cause bowel cancer

Scientists have shown how accelerated biological aging measured by an epigenetic clock may increase the risk of bowel cancer, according to a new report.

Quelle: Sciencedaily

Researchers shorten manufacturing time for CAR T cell therapy

A new approach could cut the time it takes to alter patients‘ immune cells for infusion back into the body to find and attack cancer. The cell manufacturing process for this type of immunotherapy that was pioneered at Penn — CAR T cell therapy — typically takes nine to 14 days. In a pre-clinical study, scientists have abbreviated this process and generated functional CAR T cells with enhanced anti-tumor potency in just 24 hours.

Quelle: Sciencedaily

Distinct classes of fibroblasts in tumors play opposing roles, promoting or restraining pancreatic cancer growth

Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. Appropriately targeting these cells may offer options to improve treatment outcomes.

Quelle: Sciencedaily

»Coronavirus-Update«: Vorerst letzter NDR-Podcast mit Christian Drosten und Sandra Ciesek

Nach 113 Folgen »Coronavirus-Update« verabschieden sich Virologin Sandra Ciesek und Virologe Christian Drosten. In der letzten NDR-Podcastfolge geben sie einen Ausblick auf den weiteren Verlauf der Pandemie.

Quelle: SPIEGEL ONLINE

Corona kann die Leber schädigen

Covid-19 kann viele Organe angreifen, unter anderem auch die Leber. Forscher haben herausgefunden, dass das Virus die Zellprogramme deutlich verändern und zu Folgeerkrankungen in dem Organ führen kann.

Quelle: SPIEGEL ONLINE

Black patients with cancer fare worse with COVID-19, study shows

Lack of access to health care, social determinants of health, preexisting comorbidities and reduced access to clinical research are common to both cancer and COVID-19 in Black individuals. Together these two diseases create a perfect storm in this population, a new study indicates.

Quelle: Sciencedaily

The surprising diversity of the fallopian tube

A new study creates a detailed ‚atlas‘ of the various cell types and their gene activities within the highly specialized fallopian tube, paving the way for new research into infertility and other diseases affecting this organ, including some cancers.

Quelle: Sciencedaily

Researchers offer new treatment protocol for advanced head and neck cancer

The current treatment of patients diagnosed with advanced or metastatic head and neck cancer (HNC) is ineffective. Researchers have investigated and validated a potential treatment combination against the aggressive disease driven by hyper-activation of a specific signaling pathway, which is found in over 40 percent of HNC patients.

Quelle: Sciencedaily

Potential therapy may boost chemoimmunotherapy response in bladder cancer

Adding an anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumor growth, according to a proof-of-concept study.

Quelle: Sciencedaily

Octopus-like tentacles help cancer cells invade the body

With help from the best tweezers in the world a team of researchers has shed new light on a fundamental mechanism in all living cells that helps them explore their surroundings and even invade tissue. Their discovery could have implications for research into cancer, neurological disorders and much else.

Quelle: Sciencedaily

Corona in Deutschland: Sieben-Tage-Inzidenz geht weiter zurück – auf 1700

Dem Robert Koch-Institut wurden binnen 24 Stunden 67.501 Coronainfektionen gemeldet – deutlich weniger als am vergangenen Montag. Die Gesundheitsämter registrierten zudem 20 weitere Todesopfer.

Quelle: SPIEGEL ONLINE

Corona-Krise: Sieben-Tage-Inzidenz sinkt erstmals seit einer Woche

Das Robert Koch-Institut registrierte binnen 24 Stunden 111.224 Neuinfektionen – ein Rückgang im Vergleich zum vergangenen Wochenende. 49 weitere Todesfälle sind gemeldet worden.

Quelle: SPIEGEL ONLINE

New study reveals why HIV remains in human tissue even after antiretroviral therapy

Thanks to antiretroviral therapy, HIV infection is no longer the life sentence it once was. But despite the effectiveness of drugs to manage and treat the virus, it can never be fully eliminated from the human body, lingering in some cells deep in different human tissues where it goes unnoticed by the immune system. Now, new research by University of Alberta immunologist Shokrollah Elahi reveals a possible answer to the mystery of why infected people can’t get rid of HIV altogether. Elahi and his team found that in HIV patients, killer T cells — a type of white blood cells responsible for identifying and destroying cells infected with viruses — have very little to none of a protein called CD73. Because CD73 is responsible for migration and cell movement into the tissue, the lack of the protein compromises the ability of killer T cells to find and eliminate HIV-infected cells, explained Elahi.

Quelle: Sciencedaily