Nanomedicine with siRNA shows first effectiveness against the human-pathogenic fungus Aspergillus fumigatus

A research team from Würzburg has succeeded for the first time in packaging small interfering RNAs (siRNAs) with Amphotericin B (AmB) in anionic liposomes to specifically target the dangerous mold fungus Aspergillus fumigatus. The study, published in the journal Nanoscale and highlighted on the back cover, demonstrates that this RNAi approach shuts down vital fungal genes, thereby inhibiting pathogen growth – a groundbreaking step in the development of new antifungal therapies.