How cells sort their trash

For decades it has been an open question in the ubiquitin research field how proteins are labeled as being defective or unneeded. In their recent study Brenda Schulman, Director at the Max Planck Institute (MPI) of Biochemistry, and Gary Kleiger, Chair of Chemistry and Biochemistry Department at University of Las Vegas Nevada, together with their teams were able to visualize this precise mechanism, catalyzed by the Cullin-RING Ligase E3s, for the first time. In an interview Brenda Schulman told us what led them to their findings, as well as how this knowledge may be used to help treat diseases. The results of their study are published in the journal Nature Structural and Molecular Biology.

Quelle: IDW Informationsdienst Wissenschaft