Schlagwort: stem cell
A shortage of synapses in schizophrenia?
Researchers showed that the level of synaptic impairment seen in stem cell-derived neurons of schizophrenia patients, generated from blood samples, predicted their level of cognitive impairment. This is the first time that researchers could show an intraindividual mechanistic explanation for the individual degree of schizophrenia’s cognitive symptoms. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …
Pioneering work in stem cell therapy for blood cancer: Prof. Robert Negrin receives DKMS Mechtild Harf Science Award
DKMS recognizes outstanding research and supports young scientists in the field of stem cell transplantation and cell therapy for hematological diseases at the conference of the European Society For Blood And Marrow Transplantation (EBMT) in Madrid. Quelle: IDW Informationsdienst Wissenschaft Hier jetzt das aktuell Außergewöhnliche auswählen …
Variation in cancer risk among tissues can be explained by the number of stem cell divisions
Tomasetti and Vogelstein show that the lifetime risk of cancers of many different types is strongly correlated with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to bad luck, that is, random mutations arising during DNA replication in normal, noncancerous stem cells. Tomasetti C, Vogelstein B (2015): Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 2 January 2015:…
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci
Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer1, Lothar Schermelleh and Marion Cremer Abstract Background A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome territories (CTs) in human and mouse somatic cells, and explored the spatio-temporal process of Barr body formation at onset of inactivation in early differentiating mouse embryonic stem cells (ESCs)….