A research team has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body. Using high-resolution microscopy methods, the researchers were able to show that two proteins interact dynamically with each other and thus determine whether a dying cell triggers an inflammatory reaction in the body.

High doses of a widely-used drug used in the hormonal treatment of conditions such as excessive hair growth, early puberty, prostate cancer, are linked to an increased risk of meningioma — the most common type of benign brain tumor, finds a new study of over 8-million patients.

A study has reported that the MEK inhibitor trametinib reduced the risk of disease progression or death by 52% compared to standard-of-care therapies for the treatment of low-grade serous ovarian carcinoma.

Scientists take a promising step in the direction of developing an HIV vaccine using a unique native-like trimer to develop Tier-2 neutralizing antibodies — the kind that matter for combating HIV — in mice.

Investigators have identified a germline biomarker signature that successfully predicts which patients will suffer serious side effects that occur in up to 3 in ten patients on anti-PD1/PDL1 therapy, a promising new approach to treating cancer.

A new study shows inhibition of the CECR2 gene prevents triple-negative breast cancer from advancing or metastasizing.

Castalagin, a polyphenol from the Amazonian fruit camu-camu, increases the efficacy of immunotherapy in mice by modifying their microbiome, researchers find.

Scientists have developed a novel cancer therapy that uses an MRI scanner to guide a magnetic seed through the brain to heat and destroy tumors.

A genome study to look for variants in a gene considered a fundamental building block for microscopic structures that synthesize proteins took a surprising twist.

Researchers developed a single-use sensor strip that can be used with a circuit board to detect cerebrospinal fluid leaks. They collected nine clinical samples and introduced the test fluid into a small liquid channel on the tip of the sensor strips. The liquid channel held electrodes, which contained antibodies specific to proteins found only in human cerebrospinal fluid. The circuit board analyzed the signal and produced a four-digit number that correlates to the concentration of the protein beta-2-transferrin, found in CSF.

Researchers have identified an enzyme in the thymus that is essential for immune T cells to correctly identify threats, safeguarding them from going rogue and attacking healthy tissue in the body.

A growth factor protein produced by rare immune cells in the intestine can protect against the effects of inflammatory bowel disease (IBD), according to a new discovery.

Garden soil houses a variety of bacteria and their natural byproducts — including one that may help halt tumor growth. Lankacidins are molecules that can be isolated from Strepomyces rochei, a common bacterium in soil. In addition to antimicrobial properties, a type of lankacidins, called lankacidin C, can inhibit tumor activity in various cancer cell lines, including leukemia, melanoma, ovarian and breast cancers. Lankacidin C offers a potential foundation on which to design anticancer drugs, but its structure is complicated and difficult to manipulate, according to an international research group. The same group recently identified where antitumor activity is housed on the molecule and has now used that information to simplify lankacidin as a potential starting point to engineer treatments.

The search to better understand the tremendous range of responses to infection with the COVID-19 virus — from symptom free to critically ill — has uncovered in some of the sickest patients a handful of rare structural gene variants involved in body processes, like inflammation, which the virus needs to be successful.

A protein that masterminds the way DNA is wrapped within chromosomes has a major role in the healthy functioning of blood stem cells, which produce all blood cells in the body, according to a new study.

The combination of a novel blood test and magnetic resonance imaging (MRI) can reduce overdiagnosis of low-risk cancers as well as societal costs in prostate cancer screening, according to a cost-effectiveness study.

A study has revealed a potential new way to treat secondary breast cancer that has spread to the brain, using existing drugs.

Researchers have explored the cellular changes that occur in human mammary tissue in lactating and non-lactating women, offering insight into the relationship between pregnancy, lactation, and breast cancer.

Scientists have just launched GENIGMA, a videogame that enlists players to solve puzzles while generating real-world scientific data that can detect alterations in genomic sequences and ultimately advance breast cancer research. The game was created to boost worldwide research efforts that depend on cancer cell lines, a critical resource used by scientists to study cancer and test new drugs to treat the disease. One of the limitations of cancer cell lines are a lack of high-resolution genome reference maps, which are necessary to help researchers interpret their scientific results.

A new analysis has uncovered a potential link between higher prostate cancer risk and genetic variants associated with higher bloodstream levels of the cholesterol-transporting molecule lipoprotein A.

Light therapy may accelerate the healing of skin damage from radiation therapy by up to 50%, according to a recent study.

Scientists have developed a new tool to harness immune cells from tumors to fight cancer rapidly and effectively.

Hyaluronic acid, or HA, is a known presence in pancreatic tumors, but a new study shows that hyaluronic acid also acts as food to the cancer cells. These findings provide insight into how pancreatic cancer cells grow and indicate new possibilities to treat them.

Pharmaceutical researchers speak of a hit when they come across a promising substance with a desired effect in early drug discovery. Unfortunately, hits are rarely bull’s-eyes, often showing undesirable side effects that not only complicate the search for new hits, but also the subsequent development into a drug. A new study could now help to better identify one of the most frequently observed side effects already in early drug discovery, but also to find new bioactivities.

Researchers have demonstrated that a novel combination of two drugs that act as targeted inhibitors, delivered in a nanoparticle formulation, extend the survival of mice with medulloblastoma. The research team believes this laboratory success could be translated into a less toxic treatment for medulloblastoma, the most common malignant pediatric brain tumor.