Researchers have pioneered a new method to track the progression of prostate cancer in mice, from its birth to its spread into other tissues. This approach allows researchers to study the origins of prostate cancer in a more realistic context than traditional methods allow.

Doctors and scientists have successfully tested a neoantigen-specific transgenic immune cell therapy for malignant brain tumors for the first time using an experimental model in mice.

A new study suggests that enlargement of stem cells contributes to age-related decline in function. The researchers found that blood stem cells, which are among the smallest cells in the body, lose their ability to perform their normal function — replenishing the body’s blood cells — as they grow larger. When the cells were restored to their usual size, they behaved normally again.

A team of researchers has developed a new technique to open the blood-brain barrier temporarily to deliver medication to the brain. Getting medication past the brain’s unique and protective blood vessels, known as the blood-brain barrier, is one of the biggest challenges in treating brain and central nervous system diseases, according to researchers. The technique uses light and nanoparticles to pry open temporarily these barriers — called tight junctions — to allow medication to reach its target.

Researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.

A team has developed a digital tool to better monitor a condition known as Barrett’s esophagus, which affects more than 3 million people in the United States. Barrett’s occurs when the mucosal lining of the lower esophagus deteriorates, altering its cellular structure, and is most common in those with chronic acid reflux.

A team of researchers has developed a noninvasive diagnostic method that may one day replace the biopsy with a simple blood test.

When you have become immune to malaria after having contracted the disease, it seems that the body uses a more efficient protection than if you have been vaccinated against the deadly disease. The researchers believe the new findings may be used to improve existing malaria vaccines.

A high-fat diet synergizes with exposure to PFAS to change the metabolism of benign and malignant prostate cells, according to a new study in mice.

Studying mice, researchers have developed a method of stem cell transplantation that does not require radiation or chemotherapy. Instead, the strategy takes an immunotherapeutic approach, combining the targeted elimination of blood-forming stem cells in the bone marrow with immune-modulating drugs to prevent the immune system from rejecting the new donor stem cells.

A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, researchers have discovered. They report that inhibiting or genetically deleting the enzyme, called MTHFD2, reduced disease severity in multiple inflammatory disease models.

Using an experimental system involving new genetic technology, researchers analyzed the gene expression signatures of a representative sample of barcoded leukemia cells. After implanting some of the leukemia cells in mice, they discovered that distinct gene expression signatures correlated with the various organs where the cancer cells ended up. They were also able to identify previously unknown genes that are involved in disease progression and chemotherapy resistance, which may offer new targets for treatment.

Scientists have revealed why a mutation in the UTX gene disrupts cells‘ ability to suppress tumors.

The images and accompanying data available for training artificial intelligence (AI) to spot skin cancer are insufficient and include very few images of darker skin, according to new research.

In a groundbreaking study of people living with HIV, researchers found that elusive white blood cells called neutrophils play a role in impaired T cell functions and counts, as well as the associated chronic inflammation that is common with the virus.

Exposure in utero to a drug used to prevent miscarriage can lead to an increased risk of developing cancer, according to researchers.

Scientists have identified the primary target of the experimental cancer drug CX-5164, revealing a possible risk for late effects of treatment.

A new imaging technique can measure temperature in 2D, without contact, and in just a snap.

Cancer researchers show for the first time that cellular senescence, which occurs when aging cells stop dividing, is caused by irreversible damage to the genome rather than simply by telomere erosion.

Leptin, a molecule produced by fat cells, appears to cancel out the effects of the estrogen-blocking therapy tamoxifen, a drug commonly used to treat and prevent breast cancers, suggests a new study.

Combining the immunotherapy agent durvalumab with the chemotherapy agents pemetrexed and cisplatin or carboplatin may provide a new treatment option for patients who have inoperable pleural mesothelioma, a cancer of the tissues lining the lungs, according to a phase II clinical trial.

Researchers have identified a series of symptoms associated with pancreatic cancer, including two previously unrecognised symptoms — feeling thirsty and having dark urine.

The membranes of cancer cells are more pliant than the membranes of normal cells. A research collaboration has discovered that cancer invasion and migration can be supressed in mice by manipulating the stiffness of the cell membrane. Hopefully this will contribute towards the development of new treatments that target the physical characteristics of cancer cells.

Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial.

A new study has identified an RNA molecule that suppresses prostate tumors. The scientists found that prostate cancers develop ways to shut down this RNA molecule to allow themselves to grow. According to the new research — conducted in mice implanted with human prostate tumor samples — restoring this so-called long noncoding RNA could be a new strategy to treat prostate cancer that has developed resistance to hormonal therapies.