Cancer deaths rose to 10 million worldwide in 2019

Cancer deaths rose to 10 million and new cases jumped to over 23 million globally in 2019, according to a new scientific study.

Quelle: Sciencedaily

Communication between cells plays a major role in deciding their fate

Scientists have found a way to prove that biochemical signals sent from cell to cell play an important role in determining how those cells develop, findings that can help explain how stem cells differentiate and how cancer arises and proliferates, possibly leading to new treatments.

Quelle: Sciencedaily

CBD reduces glioblastoma’s size, supportive environment in experimental model

Inhaled CBD shrinks the size of the highly aggressive, lethal brain tumor glioblastoma in an animal model by reducing the essential support of its microenvironment, researchers report.

Quelle: Sciencedaily

Dietary fiber improves outcomes for melanoma patients on immunotherapy

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration.

Quelle: Sciencedaily

Microorganism sheds new light on cancer resistance

Scientists describe T. adhaerens‘ unusual behavior, including its capacity to repair its DNA even after significant radiation damage and to extrude injured cells, which later die. The findings advance scientific investigations of natural cancer-suppression mechanisms across life. Insights gleaned from these evolutionary adaptations may find their way into new and more effective therapies for this leading killer.

Quelle: Sciencedaily

Genes are switched on in the human embryo from the get-go

Scientists have discovered that genes in human embryos rapidly become active after fertilization, opening a new window onto the start of human embryonic life.

Quelle: Sciencedaily

Study confirms nutrient’s role in childhood blood cancer

A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.

Quelle: Sciencedaily

Treatments in weeks, not months: Scientists develop ambitious pandemic response plan

An international team of scientists has created a plan for an accelerated pipeline for developing drug cocktails to battle the COVID-19 pandemic. The pipeline could speed new and better treatments that the newly diagnosed and recently exposed could take at home to prevent serious illness.

Quelle: Sciencedaily

Honing in on shared network of cancer genes

Using network modeling, researchers have honed in on a set of gene interactions that are critical to malignancy and likely to be fertile ground for broad cancer therapies.

Quelle: Sciencedaily

Pioneering new technique to barcode cells

Scientists have developed a pioneering new technique to barcode individual cells more accurately and efficiently – which could help pave the way for quicker disease diagnosis.

Quelle: Sciencedaily

Research breakthrough could see HIV drugs used to treat low-grade brain tumors

Drugs developed to treat AIDS and HIV could offer hope to patients diagnosed with the most common form of primary brain tumor. The breakthrough is significant because, if further research is conclusive, the anti-retroviral drugs could be prescribed for patients diagnosed with meningioma and acoustic neuroma brain tumors (also known as schwannoma).

Quelle: Sciencedaily

Nanoparticle therapeutic enhances cancer immunotherapy

Researchers have discovered that a nanoparticle therapeutic enhances cancer immunotherapy and is a possible new approach in treating malignant pleural effusion (MPE). MPE is the accumulation of fluid between the chest wall and lungs and is accompanied by malignant cells and/or tumors.

Quelle: Sciencedaily

New potential treatment for graft-versus-host-disease and other inflammatory disorders

Researchers have shown that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease, an inflammatory condition that develops in patients after their allogeneic hematopoietic stem cell transplantation.

Quelle: Sciencedaily

Reducing copper in the body alters cancer metabolism to reduce risk of aggressive breast cancer

Depleting copper levels may reduce the production of energy that cancer cells need to travel and establish themselves in other parts of the body by a process referred to as metastasis, according to a new study. The discovery of the underlying mechanisms of how copper depletion may help reduce metastasis in breast cancer will help inform the design of future clinical trials.

Quelle: Sciencedaily

Immune system responds to mRNA treatment for cancer, researchers find

Adding messenger RNA, or mRNA therapy improves the response to cancer immunotherapy in patients who weren’t responding to the treatment, new research shows. Immunotherapy uses the body’s immune system to prevent, control and eliminate cancer.

Quelle: Sciencedaily

For children, young adults with recurrent AML, immunotherapy shows promise

Researchers have shown, in a small clinical trial, that an immunotherapy harnessing pre-activated natural killer cells can help some children and young adults with recurrent AML and few other treatment options.

Quelle: Sciencedaily

Improving drug options for colorectal cancer patients

Patients with colorectal cancer were among the first to receive targeted therapies. These drugs aim to block the cancer-causing proteins that trigger out-of-control cell growth while sparing healthy tissues. But some patients are not eligible for these treatments because they have cancer-promoting mutations that are believed to cause resistance to these drugs. Now, physician-scientists have used computer modeling and cell studies to discover that more patients may be helped by a common class of targeted therapies than previously thought.

Quelle: Sciencedaily

Boosting anti-cancer action by driving up immunity at tumor site

Driving up the immune response at the site of a cancer tumor with nanotechnology may help enhance immunotherapy treatments in advanced stages of the disease, new research in mice suggests.

Quelle: Sciencedaily

Cancer-spotting AI and human experts can be fooled by image-tampering attacks

Artificial intelligence (AI) models that evaluate medical images have potential to speed up and improve accuracy of cancer diagnoses, but they may also be vulnerable to cyberattacks. Researchers simulated an attack that falsified mammogram images, fooling both an AI breast cancer diagnosis model and human breast imaging radiologist experts.

Quelle: Sciencedaily

Gene Network changes associated with cancer onset and progression identify new candidates for targeted gene therapy

Researchers have identified novel changes in gene network interactions associated with cancer that may lead to new treatment targets for chemotherapy. Their work shows that more than 90% of changes in gene network interactions in nine types of cancer studied are not detectable by current tests focused on changes in gene expression.

Quelle: Sciencedaily

‚Supermeres‘ may carry clues to cancer, Alzheimer’s disease and COVID-19

Researchers have discovered a nanoparticle released from cells, called a ’supermere,‘ which contains enzymes, proteins and RNA associated with multiple cancers, cardiovascular disease, Alzheimer’s disease and even COVID-19.

Quelle: Sciencedaily

Research demonstrates that cells with cancer-associated mutations overtake human tissue with age

Recently published research has found that most cancer-free individuals over age 60 carry at least 100 billion cells harboring at least one oncogenic, or tumor-causing, mutation.

Quelle: Sciencedaily

Cannabis use could cause harmful drug interactions

Using cannabis alongside other drugs may come with a significant risk of harmful drug-drug interactions, new research suggests. The researchers looked at cannabinoids–a group of substances found in the cannabis plant — and their major metabolites found in cannabis users‘ blood and found that they interfere with two families of enzymes that help metabolize a wide range of drugs prescribed for a variety of conditions. As a result, either the drugs‘ positive effects might decrease or their negative effects might increase with too much building up in the body, causing unintended side effects such as toxicity or accidental overdose. While more research needs to be done, the authors said one early takeaway from these studies is that it’s important to be careful when using cannabis with other prescription drugs.

Quelle: Sciencedaily

Scientists identify malfunctioning brain cells as potential target for Alzheimer’s treatment

Scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer’s disease treatment.

Quelle: Sciencedaily

Research reveals how aging cells can be an underlying cause of kidney damage

A study in mice has found that stress and tissue damage initiated by angiotensin II, a molecule that is known to increase blood pressure and stiffening in the linings of blood vessels, leads to cellular senescence, a process by which a cell ages and permanently stops dividing but does not die. Importantly, when the researchers eliminated senescent cells from the mice, tissues returned to a normal state in spite of a continued infusion of angiotensin II.

Quelle: Sciencedaily