Scientists identify a pathway of immune cell inhibition that may provide the basis for novel approaches to immunotherapy of colon cancer. Their results also highlight important roles of the intestinal microbiota in the development of the disease.

Searching for ways to extend the survival benefit of targeted therapies, a team led by researchers has identified a potential new tactic to disrupt the repair mechanism that cancer cells use after treatment, blunting their ability to regenerate. The approach could present a new treatment strategy.

Global opioid sales increased by an estimated 4% annually from 2015 to 2019, but massive disparities in access to essential pain relief medications persist between countries, a new study finds.

A study is the first in North America to demonstrate that living-donor liver transplant is a viable option for patients who have systemically controlled colorectal cancer and liver tumors that cannot be surgically removed.

A study is the first in North America to demonstrate that living-donor liver transplant is a viable option for patients who have systemically controlled colorectal cancer and liver tumors that cannot be surgically removed.

Scientists are using zebrafish to understand human skin cancer that attacks the hands and feet.

Scientists are using zebrafish to understand human skin cancer that attacks the hands and feet.

Researchers have found that treatment with miR-634 reduces the resistance of oral squamous cell carcinoma cells to cisplatin, resulting in increased tumor cell killing. An ointment containing miR-634 had a similar effect in mice, suggesting that this simple topical treatment could be used to improve the prognosis of patients with advanced oral cancer.

Researchers have found that treatment with miR-634 reduces the resistance of oral squamous cell carcinoma cells to cisplatin, resulting in increased tumor cell killing. An ointment containing miR-634 had a similar effect in mice, suggesting that this simple topical treatment could be used to improve the prognosis of patients with advanced oral cancer.

Researchers have discovered that a protein critical in the embryonic stages of life is reactivated in certain cases of mesothelioma, offering clues into the origin of this aggressive cancer.

An algorithm which can predict how long a patient might spend in hospital if they’re diagnosed with bowel cancer could save the money and help patients feel better prepared.

Researchers have identified a four-protein complex that appears to play a key role in generating ribosomes — organelles that serve as protein factories for cells — as well as a surprising part in neurodevelopmental disorders. The findings could lead to new ways to manipulate ribosome production, which could impact a variety of conditions that affect human health.

Ten-second videos of white blood cell motion in the skin’s microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.

Scientists have shown how accelerated biological aging measured by an epigenetic clock may increase the risk of bowel cancer, according to a new report.

A new approach could cut the time it takes to alter patients‘ immune cells for infusion back into the body to find and attack cancer. The cell manufacturing process for this type of immunotherapy that was pioneered at Penn — CAR T cell therapy — typically takes nine to 14 days. In a pre-clinical study, scientists have abbreviated this process and generated functional CAR T cells with enhanced anti-tumor potency in just 24 hours.

Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. Appropriately targeting these cells may offer options to improve treatment outcomes.

Lack of access to health care, social determinants of health, preexisting comorbidities and reduced access to clinical research are common to both cancer and COVID-19 in Black individuals. Together these two diseases create a perfect storm in this population, a new study indicates.

A new study creates a detailed ‚atlas‘ of the various cell types and their gene activities within the highly specialized fallopian tube, paving the way for new research into infertility and other diseases affecting this organ, including some cancers.

The current treatment of patients diagnosed with advanced or metastatic head and neck cancer (HNC) is ineffective. Researchers have investigated and validated a potential treatment combination against the aggressive disease driven by hyper-activation of a specific signaling pathway, which is found in over 40 percent of HNC patients.

Adding an anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumor growth, according to a proof-of-concept study.

With help from the best tweezers in the world a team of researchers has shed new light on a fundamental mechanism in all living cells that helps them explore their surroundings and even invade tissue. Their discovery could have implications for research into cancer, neurological disorders and much else.

Thanks to antiretroviral therapy, HIV infection is no longer the life sentence it once was. But despite the effectiveness of drugs to manage and treat the virus, it can never be fully eliminated from the human body, lingering in some cells deep in different human tissues where it goes unnoticed by the immune system. Now, new research by University of Alberta immunologist Shokrollah Elahi reveals a possible answer to the mystery of why infected people can’t get rid of HIV altogether. Elahi and his team found that in HIV patients, killer T cells — a type of white blood cells responsible for identifying and destroying cells infected with viruses — have very little to none of a protein called CD73. Because CD73 is responsible for migration and cell movement into the tissue, the lack of the protein compromises the ability of killer T cells to find and eliminate HIV-infected cells, explained Elahi.

Scientists have now created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin receptor, as well as vulnerable proteins on the surface of viruses. This solves a long-standing challenge in drug development and may lead to new treatments for cancer, diabetes, infection, inflammation, and beyond.

Researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.

The A2A receptor regulates how vigorously the innate immune system attacks diseased cells. Researchers have now been able to show for the first time how an important inhibitor binds to the receptor. In the future, the results will facilitate the targeted search for molecules that give the innate immune system more punch. These could for instance be used in the fight against cancer, but also against brain diseases such as Alzheimer’s or Parkinson’s disease.