Schlagwort: HIV
Blutspende: Großbritannien schafft diskriminierende Regel für viele Schwarze ab
Stigmatisierung verhindert Lehren aus der HIV-Pandemie
Die HIV-Pandemie traf besonders früh die LGBTQI*-Gemeinschaft: Menschen, die ohnehin schon stigmatisiert wurden. Diese Stigmatisierung verhinderte, dass breitere Teile der Gesellschaft die Lehren aus der HIV-Pandemie übernahmen – mit Folgen für den Umgang mit der Covid-19-Pandemie, argumentieren Wissenschaftler*innen der Fakultät für Gesundheitswissenschaften der Universität Bielefeld. Im Fachmagazin Science zeigen sie, wie die Gesellschaft aus den Erfahrungen stigmatisierter Gemeinschaften besser lernen könnte.
A global assessment of cancer genomic alterations in epigenetic mechanisms
Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira
Abstract
Background
The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients.
Results
Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover a general trend in which transcriptional profiles and somatic mutations in tumor samples favor increased transcriptionally repressive histone methylation, and defective chromatin remodeling.
Conclusions
This unbiased approach confirms previously published data, uncovers novel cancer-associated aberrations targeting epigenetic mechanisms, and justifies continued monitoring of chromatin-related alterations as a class, as more cancer types and distinct cancer stages are represented in cancer genomics data repositories.
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