Scientists have revealed why a mutation in the UTX gene disrupts cells‘ ability to suppress tumors.

The images and accompanying data available for training artificial intelligence (AI) to spot skin cancer are insufficient and include very few images of darker skin, according to new research.

Scientists have identified the primary target of the experimental cancer drug CX-5164, revealing a possible risk for late effects of treatment.

Exposure in utero to a drug used to prevent miscarriage can lead to an increased risk of developing cancer, according to researchers.

Leptin, a molecule produced by fat cells, appears to cancel out the effects of the estrogen-blocking therapy tamoxifen, a drug commonly used to treat and prevent breast cancers, suggests a new study.

Combining the immunotherapy agent durvalumab with the chemotherapy agents pemetrexed and cisplatin or carboplatin may provide a new treatment option for patients who have inoperable pleural mesothelioma, a cancer of the tissues lining the lungs, according to a phase II clinical trial.

The membranes of cancer cells are more pliant than the membranes of normal cells. A research collaboration has discovered that cancer invasion and migration can be supressed in mice by manipulating the stiffness of the cell membrane. Hopefully this will contribute towards the development of new treatments that target the physical characteristics of cancer cells.

Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial.

A new study has identified an RNA molecule that suppresses prostate tumors. The scientists found that prostate cancers develop ways to shut down this RNA molecule to allow themselves to grow. According to the new research — conducted in mice implanted with human prostate tumor samples — restoring this so-called long noncoding RNA could be a new strategy to treat prostate cancer that has developed resistance to hormonal therapies.

New findings help better understand the how one of the most commonly mutated genetic drivers of cancer passes signals that cause the disease.

A new finding offers researchers a direct way to investigate oxidative stress and its damaging effects in aging, cancer and other diseases.

An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a reduction in tumor growth, and in some mice, eliminating their cancer.

Copper has been clinically improving the lives of people since about 1500 BCE, when an Egyptian physician first recorded its use as a treatment for inflammation. Some 35 centuries later, researchers have provided solid evidence that the first metal used medicinally may now have a new role — helping save children from a devastating central nervous system cancer known as medulloblastoma.

Researchers have identified a key molecule in certain kinds of breast cancers that prevent immune cells from entering tumors and killing the cancer cells inside. This research could pave the way toward a new treatment for certain kinds of aggressive breast cancer.

In a breakthrough for the treatment of aggressive solid cancers, researchers have developed a novel cancer therapy that targets proteins inside cancer cells that are essential for tumor growth and survival but have been historically impossible to reach. Using the power of large data sets and advanced computational approaches, the researchers were able to identify peptides that are presented on the surface of tumor cells and can be targeted with ‚peptide-centric‘ chimeric antigen receptors (PC-CARs), a new class of engineered T cells, stimulating an immune response that eradicates tumors.

Researchers have shown that a prostate cancer urine test can identify men at ‚intermediate risk‘ who can safely avoid immediate treatment and benefit from ‚active surveillance‘ instead. Previously, the team’s Prostate Urine Risk (PUR) test could identify men with high and low risk cancers. But thanks to some fine-tuning, it can now help men with intermediate-risk disease – for whom treatment options had been less clear.

A researcher found that artificial intelligence can accurately detect and diagnose colorectal cancer from tissue scans as well or better than pathologists, according to a new study.

A new study adds to the evidence that chemotherapy enhances cancer’s spread beyond the primary tumor, showing how one chemo drug allows breast cancer cells to squeeze through and attach to blood vessel linings in the lungs.

A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes. Medical researchers have now developed a new drug-like molecule that can counteract the effects of mutated epigenetic regulators, which are known to drive certain types of cancer including lymphoma.

Pioneering research shows that acinar cells in the pancreas form new cell types to mitigate injury but are then susceptible to cancerous mutations.

Molecular targets for therapies that could prevent breast cancer recurrence have been identified by a group of scientists who analyzed tumor cells that proved resistant to the original treatment. Recent advances in early detection and targeted therapy have led to a growing success in treating breast cancer upon first presentation. This often is achieved by silencing tumor driving oncogenes and causing tumor regression.

A non-toxic, bacteria-based system can detect when it is inside a cancer cell and then release its payload of therapeutic drugs directly into the cell. The work could lead to effective, targeted therapies for currently untreatable cancers, such as liver or metastatic breast cancer.

A new model sheds light on the function of a protein that is a major player in cancer growth, and their results could one day help researchers determine better ways to stop the spread of cancer.

Researchers have discovered a new way to jump-start the immune system to attack tumors, which could allow cancer immunotherapy to be used against more types of cancer.

Researchers have made recommendations for clinicians and patients regarding supplemental screening for women with dense breast tissue.