MEDIZIN.NEWZS.de – Quantum Related Diseases Research Group (QRDRG)

Das Paul-Ehrlich-Institut hat vielen Antigenschnelltests ein gutes Zeugnis beim Omikron-Nachweis ausgestellt. Zu Unrecht, meint der Münchner Virologe Oliver Keppler, die Studie sei unzulänglich. Kritik gibt es vor allem an der Stichprobe.

Die Gefahr eines Diabetesleidens kann lange nach einer Covid-19-Infektion offenbar deutlich erhöht sein – selbst bei milden Verläufen. Eine deutsche und eine US-Studie suchen die Risikofaktoren und vergrößern die Long-Covid-Sorgen.

Researchers have identified a four-protein complex that appears to play a key role in generating ribosomes — organelles that serve as protein factories for cells — as well as a surprising part in neurodevelopmental disorders. The findings could lead to new ways to manipulate ribosome production, which could impact a variety of conditions that affect human health.

Ten-second videos of white blood cell motion in the skin’s microvasculature greatly improved the prediction of which stem cell and bone marrow transplant patients would have a relapse of their blood cancer.

Scientists have shown how accelerated biological aging measured by an epigenetic clock may increase the risk of bowel cancer, according to a new report.

A new approach could cut the time it takes to alter patients‘ immune cells for infusion back into the body to find and attack cancer. The cell manufacturing process for this type of immunotherapy that was pioneered at Penn — CAR T cell therapy — typically takes nine to 14 days. In a pre-clinical study, scientists have abbreviated this process and generated functional CAR T cells with enhanced anti-tumor potency in just 24 hours.

Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. Appropriately targeting these cells may offer options to improve treatment outcomes.

Nach 113 Folgen »Coronavirus-Update« verabschieden sich Virologin Sandra Ciesek und Virologe Christian Drosten. In der letzten NDR-Podcastfolge geben sie einen Ausblick auf den weiteren Verlauf der Pandemie.

Covid-19 kann viele Organe angreifen, unter anderem auch die Leber. Forscher haben herausgefunden, dass das Virus die Zellprogramme deutlich verändern und zu Folgeerkrankungen in dem Organ führen kann.

Lack of access to health care, social determinants of health, preexisting comorbidities and reduced access to clinical research are common to both cancer and COVID-19 in Black individuals. Together these two diseases create a perfect storm in this population, a new study indicates.

A new study creates a detailed ‚atlas‘ of the various cell types and their gene activities within the highly specialized fallopian tube, paving the way for new research into infertility and other diseases affecting this organ, including some cancers.

The current treatment of patients diagnosed with advanced or metastatic head and neck cancer (HNC) is ineffective. Researchers have investigated and validated a potential treatment combination against the aggressive disease driven by hyper-activation of a specific signaling pathway, which is found in over 40 percent of HNC patients.

Adding an anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumor growth, according to a proof-of-concept study.

With help from the best tweezers in the world a team of researchers has shed new light on a fundamental mechanism in all living cells that helps them explore their surroundings and even invade tissue. Their discovery could have implications for research into cancer, neurological disorders and much else.

Dem Robert Koch-Institut wurden binnen 24 Stunden 67.501 Coronainfektionen gemeldet – deutlich weniger als am vergangenen Montag. Die Gesundheitsämter registrierten zudem 20 weitere Todesopfer.

Das Robert Koch-Institut registrierte binnen 24 Stunden 111.224 Neuinfektionen – ein Rückgang im Vergleich zum vergangenen Wochenende. 49 weitere Todesfälle sind gemeldet worden.

Thanks to antiretroviral therapy, HIV infection is no longer the life sentence it once was. But despite the effectiveness of drugs to manage and treat the virus, it can never be fully eliminated from the human body, lingering in some cells deep in different human tissues where it goes unnoticed by the immune system. Now, new research by University of Alberta immunologist Shokrollah Elahi reveals a possible answer to the mystery of why infected people can’t get rid of HIV altogether. Elahi and his team found that in HIV patients, killer T cells — a type of white blood cells responsible for identifying and destroying cells infected with viruses — have very little to none of a protein called CD73. Because CD73 is responsible for migration and cell movement into the tissue, the lack of the protein compromises the ability of killer T cells to find and eliminate HIV-infected cells, explained Elahi.

Scientists have now created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin receptor, as well as vulnerable proteins on the surface of viruses. This solves a long-standing challenge in drug development and may lead to new treatments for cancer, diabetes, infection, inflammation, and beyond.

Researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.

Das Robert Koch-Institut hat 252.026 Corona-Neuinfektionen registriert. Die Sieben-Tage-Inzidenz hat sich demnach minimal erhöht. Binnen 24 Stunden sind 278 weitere Menschen im Zusammenhang mit dem Virus gestorben.

The A2A receptor regulates how vigorously the innate immune system attacks diseased cells. Researchers have now been able to show for the first time how an important inhibitor binds to the receptor. In the future, the results will facilitate the targeted search for molecules that give the innate immune system more punch. These could for instance be used in the fight against cancer, but also against brain diseases such as Alzheimer’s or Parkinson’s disease.

Half of all women experience a false positive mammogram after 10 years of annual breast cancer screening with 3D mammography, a UC Davis-led study estimates. This risk was lower for women who had mammograms every other year. 3D screening showed slightly lower false positive results than standard mammography.

Treatment for glioma has long relied on MRI imaging to track tumor markers and treatment response. But new findings suggest a new method could provide additional data about tumor markers before changes appear on an MRI, indicating possible strategies to help clinicians address this aggressive form of cancer.

Researchers have developed a novel method to identify aggressive early-stage lung cancers and target drugs known as aurora kinase inhibitors to tumors that are especially likely to respond to them. The findings could lead to great advances in treatment for lung adenocarcinoma, the most common type of lung cancer.

Corona, so wird oft behauptet, verläuft glimpflich in den jungen Gesellschaften Afrikas. Forscher haben nun in Sambia Tote untersucht – und sehr viele Coronaviren gefunden.