Frailty is a condition characterized by increased vulnerability and decline in physical function. It’s a growing concern in the aging population, particularly among those with heart disease. A multidisciplinary research team led by the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), the Faculty of Health Sciences (FGW) at the University of Potsdam and Deutsches Herzzentrum der Charité has now identified the gene S100A1 as a potential biomarker and therapeutic target in muscle tissue of older patients with heart disease, offering the potential to counteract mobility loss and muscle weakness early on. The findings were published in the Journal of Cachexia, Sarcopenia and Muscle.