ENDOTARGET aimed at investigating the relationship between gut microbiota, intestinal permeability, and systemic endotoxemia to unravel the triggering factors for health-to-disease transition in rheumatic diseases such as osteoarthritis (OA), rheumatoid arthritis (RA), and spondylarthritis (SpA), has achieved significant milestones since its start on January 1st, 2023. The project is funde by the EU with 7 million euros.