In a first-of-its-kind commentary published March 14, 2024, in the journal Cell, 24 transgender scientists and their family members openly share their experiences in STEMM (science, technology, engineering, mathematics, and medicine) fields. The landmark commentary is featured in a sex- and gender-focused issue of Cell that covers a range of topics, including gender equity, the history of sex and gender research, and ways to improve the quality of research by incorporating more rigorous sex-related variables.