Cycle of fasting and feeding is crucial for healthy ageing: Genetic switch rescues old fish from fasting trap

Health is thought to be improved by fasting interventions, which involve alternating periods of fasting and feeding. But this doesn’t work as well in old animals. By studying the short-lived killifish, researchers at the Max Planck Institute for Biology of Ageing in Cologne have shown that older fish deviate from a youthful fast and refeed cycle, and instead enter a state of perpetual fasting, even when feeding. However, the benefits of refeeding after fasting in old killifish can be restored by genetically activating a specific subunit of AMP kinase. These fish experienced improved health and longevity, indicating that both fasting and refeeding are needed to confer health benefits.

Quelle: IDW Informationsdienst Wissenschaft