Bypassing side effects: Nanocontainers transport active ingredients directly to their target

Using nanoparticles, a Jena research team implemented the targeted transport of an active ingredient into liver tissue. The particles were functionalized with a dye that is specifically absorbed by liver cells, and they carried an inhibitor of the signal protein PI3Kinase γ, which contributes to the development of liver failure in sepsis. However, outside liver cells, the signal protein is involved in pathogen reduction; this desired immune activity remained unhindered. This novel approach to the treatment of septic liver failure has recently been published in EMBO Molecular Medicine.

Quelle: IDW Informationsdienst Wissenschaft