Dresden researchers discover resistance mechanism in aggressive cancer

Protease blocks guardian function against uncontrolled cell division

Researchers of the Carl Gustav Carus University Hospital Dresden at the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international team of researchers, have deciphered a previously unknown survival mechanism in the nucleus of particularly aggressive tumor cells. Accumultion of the protein-cleaving enzyme (protease) caspase 8, in the nucleus of particularly aggressive cancer cells, plays an important role here. If the enzyme could be chemically inhibited at this point, it might be possible to effectively combat various types of cancer, even in advanced progression stages.

Quelle: IDW Informationsdienst Wissenschaft