When healthy cells stimulate the migration of tumor cells

Estrogens act as a driving force of both healthy and cancerous mammary cell growth by binding to receptors that include GPER, which is generally located in cell membranes. Studies have revealed the unusual presence of this receptor in the nuclei of fibroblasts surrounding mammary tumor cells. Researchers have discovered that this is in fact another version of GPER with different properties. The fibroblasts carrying this variant promote the migration of neighboring malignant cells. (Mehr in: Cancer News — ScienceDaily)