MDC Researchers Uncover Regulatory Network in the Kidney

The kidney carries out vital functions by continuously filtering the blood and excreting waste products into the urine. This is achieved by a complex system of tubules which transports the urine and regulates its composition. PhD student Annekatrin Aue, Dr. Christian Hinze and Professor Kai Schmidt-Ott of the Max Delbrück Center for Molecular Medicine (MDC) have now discovered how parts of these kidney tubules establish an inner space (lumen) and form a tight barrier against adjacent structures. The epithelial cells which line the tubules coordinate these processes through a novel molecular signaling pathway (Journal of the American Society of Nephrology, doi: 10.1681/ASN.2014080759)1. (Mehr in: Pressemitteilungen – idw – Informationsdienst Wissenschaft)