Schlagwort: tumor
Researchers reduce breast cancer metastasis in animal models by modifying tumor electrical properties
CBD reduces glioblastoma’s size, supportive environment in experimental model
Boosting anti-cancer action by driving up immunity at tumor site
Magnetic resonance imaging (MRI) and artificial intelligence (AI) can detect early signs of tumor cell death after novel therapy
Parallels in human, dog oral tumors could speed new therapies
Noninvasive brain biopsy shows improved sensitivity in tumor detection
New strategy against treatment-resistant prostate cancer identified
Experimental drug boosts immunotherapy effectiveness in pancreatic cancer in mice
Researchers develop a new class of CAR-T cells that target previously untargetable cancer drivers
Metabolic memory plays a key role in breast cancer relapse
Under arrest: Using nanofibers to stop brain tumor cells from spreading
New way to find cancer at the nanometer scale
Molecular atlas of small cell lung cancer reveals unusual cell type that could explain why it’s so aggressive
Fluorescent spray lights up tumors for easy detection during surgery
Break through the tumor’s protective shield
Common diabetes drug promising against rare childhood brain tumor in laboratory studies
Super-enhancers: The villain fueling certain cancers
The immune system’s double agents
Cell labelling method from microscopy adapted for use in whole-body imaging
Counting cells may shed light on how cancer spreads
Targeting a rare secondary cancer in children
Lab grown tumor models could improve treatment for pancreatic cancer
A global assessment of cancer genomic alterations in epigenetic mechanisms
Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira
Abstract
Background
The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients.
Results
Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover a general trend in which transcriptional profiles and somatic mutations in tumor samples favor increased transcriptionally repressive histone methylation, and defective chromatin remodeling.
Conclusions
This unbiased approach confirms previously published data, uncovers novel cancer-associated aberrations targeting epigenetic mechanisms, and justifies continued monitoring of chromatin-related alterations as a class, as more cancer types and distinct cancer stages are represented in cancer genomics data repositories.
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Implications of quantum metabolism and natural selection for the origin of cancer cells and tumor progression
Energy transfer in material solids is driven primarily by differences in intensive thermodynamic quantities such as pressure and temperature. The crucial observation in quantum-theoretical models was the consideration of the heat capacity as associated with the vibrations of atoms in a crystalline solid. However, living organisms are essentially isothermal. Because of very little differences in temperature between different parts of a cell it is assumed that energy flow in living organisms is mediated by differences in the turnover time of various metabolic processes in the cell, which occur in cyclical fashion. It has been shown that the cycle time of these metabolic processes is related to the metabolic rate, that is the rate at which the organism transforms the free energy of whatever source into metabolic work, maintenance of constant temperature and structuraland functional organization of the cells. Quantum Metabolism exploits the methodology of the quantum theory of solids to provide a molecular level which derives new rules relating metabolic rate and body size.
Einstein A (1920), Schallausbreitung in teilweise dissozieirten Gasen
Einstein A (1924) Quantentheorie des einatomigen, idealen Gases
A new theory of the origin of cancer: quantum coherent entanglement, centrioles, mitosis, and differentiation
Low non-specific, low intensity laser illumination (635, 670 or 830 nm) apparently enhances centriole replication and promotes cell division, what is the opposite of a desired cancer therapy. In the contrary, centrioles are sensitive to coherent light. Then higher intensity laser illumination – still below heating threshold – may selectively target centrioles, impair mitosis and be a beneficial therapy against malignancy. If centrioles utilize quantum photons for entanglement, properties of centrosomes/centrioles approached more specifically could be useful for therapy. Healthy centrioles for a given organism or tissue differentiation should then have specific quantum optical properties detectable through some type of readout technology. An afflicted patient’s normal cells could be examined to determine the required centriole properties which may then be used to generate identical quantum coherent photons administered to the malignancy. In this mode the idea would not be to destroy the tumor – relatively low energy lasers would be used – but to “reprogram” or redifferentiate the centrioles and transform the tumor back to healthy well differentiated tissue.
