A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans — including SARS-CoV-2, the cause of COVID-19 — may be possible, say researchers.

Scientists have developed mathematical models that act as patient ’surrogates‘ for evaluating potential prostate cancer treatments.

Researchers found that some cancer cells weave a deactivating signal into a protective coat of armor, immobilizing and excluding T cells that would otherwise kill them. This immune deactivation pathway offers a promising new therapeutic approach for pancreatic, breast, and colorectal cancers.

Researchers surveyed and compared early- and late-stage breast and colorectal cancer diagnoses in patients in pre-pandemic 2019 and in 2020, the first full year of the COVID-19 pandemic, discovering fewer of the former and more of the latter as patients delayed care.

A new study shows ixabepilone plus bevacizumab (IXA+BEV) is a well-tolerated, effective combination for treatment of platinum/taxane-resistant ovarian cancer compared to ixabepilone (IXA) alone.

A study is validating the use of genomic sequencing to predict the likelihood that patients with gastric cancer will derive benefit from chemotherapy or from immunotherapy.

A new study found in a living embryo that the back ends of moving cell groups push the group forward, with implications for how organs form and cancer spreads.

Nanomaterials have revolutionized the world of cancer therapy, and plant-derived nanoparticles have the added advantage of being cost-effective and easy to mass produce. Researchers have recently developed novel corn-derived bionanoparticles for targeting cancer cells directly, via an immune mechanism. The results are encouraging, and the technique has demonstrated efficacy in treating tumor-bearing laboratory mice. Moreover, no serious adverse effects have been reported in mice so far.

Bile duct cancer, also known as cholangiocarcinoma (CCA), is a rare cancer often diagnosed only at an advanced stage. A comprehensive analysis of diagnostic, prognostic, and therapeutic aspects of over 2,200 patients in Europe now provides a valuable knowledge base for raising awareness and managing CCA to improve outcomes.

Researchers discovered how ovarian cancer hides from the body’s immune system. The findings will help develop novel precision therapies for ovarian cancer, a common and aggressive cancer type.

A new study shows how two subsets of one type of immune cell — the CD8 T cell — develop to provide either short-term or long-term immune protection. The study focuses on one factor that guides that developmental bifurcation — interleukin-2, or IL-2.

Researchers have created a functional catalog of proteins that activate gene expression, with implications for tailored therapy for cancer and other diseases that occur when wrong genes are switched on.

A research team introduces a new large-scale study on human transcription factors combining two state-of-the art interactomics methods that allow rapid identification of protein-protein interactions and extensive functional information of this important gene family.

Researchers have discovered that metabolic changes affect how blood cells are formed during embryonic development. They found a previously unknown metabolic switch with a key role in how different types of blood cells develop. This means blood cell formation can be directed towards producing natural killer cells in the laboratory to ultimately be used in a new anti-cancer treatment.

Researchers have identified a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome. These mutation clusters contribute to the progression of about 10% of human cancers and can be used to predict patient survival.

Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types. Their findings provide a potential roadmap for metastatic tumor formation that could be used to design therapies to improve the treatment of metastasized patients.

According to a new study, thawing of permafrost due to climate change could expose the Arctic population to much greater concentrations of the invisible, lung cancer-causing gas Radon.

Researchers discover a ’switch‘ specific to transcription factors that induce the genes essential for blood vessel development in postnatal periods. Mouse models further showed that the modifiers responsible for the switch are critical for postnatal angiogenesis.

Researchers have shown how probiotic bacteria in the gut could undermine immunity in pancreatic cancer, pointing toward more personalized cancer treatments.

When tumors spread, cancer cells migrate to other parts of the body through the blood or lymphatic vessels. Scientists have now found a new protein that prevents cancer cells from doing so by making them stick more tightly to their surroundings. Their findings could in the future help doctors determine the aggressiveness of a tumor and fine-tune the therapy.

In many mammals including humans, the placenta invades the wall of the uterus during pregnancy in the same way that cancer cells invade surrounding tissues. Using genomic sequences and gene expression information, researchers were able to predict specific signaling proteins that drive the expression of genes that decrease the susceptibility of invasion in human cells. Using a custom fabricated bio chip, the researchers confirmed that these predicted proteins did in fact decrease the invasion of both cancer and placental cells.

A new study demonstrates the ability of the mutant Kras oncogene to use genetic reprogramming to make cells more stem-like and plastic; it resolves the long-standing debate over why Kras is so special in tumor formation. They were also able to identify an effector complex that can be targeted for therapeutic treatment against mutant Kras.

Researchers have developed a new protocol for monitoring acute lymphoblastic leukemia (ALL), the most common cancer in children, to inform more effective treatment strategies and detect disease recurrence. The personalized mediator probe PCR (MP PCR) uses multiple genomic cancer cell markers in a single assay and is simpler than current techniques. It improves monitoring clonal tumor evolution to detect a relapse sooner and avoid false negative results.

Mice are typically used as models in advanced prostate cancer research, but the profound differences between them and humans has long bedeviled the translation of findings from the animal to success in people. Dogs however are the only other animal that suffers from a significant incidence of prostate cancer, and researchers are finding them much more enlightening subjects in identification of drugs that show promise for human patients.

Scientists believe it may be possible to prevent DNA changes driven by two proteins highly active in leukemia and other cancers. They recently reported a new mechanistic target for drug development.