A new computational approach successfully combines data from parallel gene-expression profiling methods to create spatial maps of a given tissue at single-cell resolution. The resulting maps can provide unique biological insights into the cancer microenvironment and many other tissue types.

A new form of magnetic resonance imaging (MRI) that makes cancerous tissue glow in medical images could help doctors more accurately detect and track the progression of cancer over time.

A researcher has found, through extensive data analysis, that the youngest patients with brain tumors — those ages birth to 3 months — have about half the five-year survival rate as children ages 1 to 19.

New research finds that patients with ASXL1-mutant chronic myelomonocytic leukemia — an uncommon type of cancer of the bone marrow — have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster. The ASXL1 genetic mutation also can transform the disease into the more aggressive acute myeloid leukemia.

Researchers have described application of a pioneering chemical technique which could unlock ground-breaking new treatments for cancer and other diseases.

Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of death worldwide. However, why premenopausal women are more resistant to NAFLD than men is currently unknown. Now, scientists demonstrate, through sex-balanced experiments on mice, that the female liver produces higher levels of a protein that has a protective effect against NAFLD. Their findings could lead to new therapeutic strategies for treating NAFLD.

An artificial intelligence (AI) tool can accurately and consistently classify breast density on mammograms, according to a new study.

Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumor. Researchers are now on a method to detect these cells.

Researchers have genetically engineered a microbial encapsulation system for therapeutic bacteria that can hide them from immune systems, enabling them to reach tumors more effectively and kill cancer cells in mice.

New research has linked phthalates, commonly called the ‚everywhere chemical,‘ to higher incidence of specific childhood cancers.

A new protein subunit vaccine may offer an inexpensive, easy-to-store, and effective alternative to RNA vaccines for COVID-19.

A research team has discovered novel metabolic mechanisms that contribute to how ovarian cancer escapes from immune attack, and how combination therapies can exploit these pathways to improve ovarian cancer treatment.

Tumors can use an enzyme called ART1 to thwart antitumor immune cells, making the enzyme a promising new target for immunity-boosting cancer treatments, according to a new study.

Scientists have developed a genetic screening platform to identify genes that can enhance immune cells to make them more persistent and increase their ability to eradicate tumor cells.

Different activity in two molecular networks could help explain why triple negative breast cancers tend to be more aggressive in African American (AA) women compared with white American (WA) women, a new study suggests.

Treating cancer and other diseases with laser light is not currently considered routine, but new approaches using nanoparticles show some promise in improving existing techniques. Researchers review the status of the field and by combining photothermal therapy or photodynamic therapy with nanomaterials, they have been able to apply these types of phototherapies while also delivering drugs to sites in the body that are otherwise inaccessible. It is also possible to combine PTT and PDT into a single treatment, creating an even more powerful treatment method.

A new study suggests that the malaria drug hydroxychloroquine inhibits pathways that drive resistance to the chemotherapy agent cisplatin in head and neck cancers and restores tumor-killing effects of cisplatin in animal models.

Having dense breasts (more fibroglandular tissue than fatty tissue, as visualized on a mammogram) reduces the sensitivity of mammography by masking breast cancers and carries a 1.6- to 2.0-fold increased independent risk for breast cancer. To inform women about these risks, 38 U.S. states and the federal government have enacted legislation requiring a written dense breast notification (DBN) of a patient’s breast density after a mammogram, but there still is limited evidence about what breast density means, and what the implications are, to women. According to a new study, while women are receiving these notifications about their breast density, not all recipients are fully understanding what they mean in terms of future health implications. Boston University School of Medicine researchers suggest that knowledge about breast density and its associated risks is partly linked to women’s race/ethnicity and health literacy.

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers have now found an unusual way of stabilizing the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells.

Irradiation with fast protons is a more effective and less invasive cancer treatment than X-rays. However, modern proton therapy requires large particle accelerators, which has experts investigating alternative accelerator concepts, such as laser systems to accelerate protons. Such systems are deployed in preclinical studies to pave the way for optimal radiation therapy. A research team has now successfully tested irradiation with laser protons on animals.

New research has begun to unravel the mystery of why a particular form of leukaemia in infants has defied efforts to improve outcomes, despite significant improvements in treating older children. Scientists have now found subtle differences in the cell type that causes B acute lymphoblastic leukaemia (B-ALL) that may help to explain why some cases are more severe than others.

Researchers have been able to re-engineer red blood cells and use them as a promising new vehicle for vaccine delivery.

Both nanomedicines and metronomic scheduling — when medications are given at lower, more frequent doses — can correct abnormalities surrounding tumors that help protect cancer cells and foster their growth and spread. Combining nanomedicines and metronomic scheduling may help improve cancer treatment strategies.

Scientists have identified a way to ’supercharge‘ tumor-attacking T cells, a finding that may not only improve the effectiveness of a promising type of cell-based cancer immunotherapy but also expand the number of cancers it can treat.

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers.