Researchers have genetically engineered a microbial encapsulation system for therapeutic bacteria that can hide them from immune systems, enabling them to reach tumors more effectively and kill cancer cells in mice.

New research has linked phthalates, commonly called the ‚everywhere chemical,‘ to higher incidence of specific childhood cancers.

A new protein subunit vaccine may offer an inexpensive, easy-to-store, and effective alternative to RNA vaccines for COVID-19.

A research team has discovered novel metabolic mechanisms that contribute to how ovarian cancer escapes from immune attack, and how combination therapies can exploit these pathways to improve ovarian cancer treatment.

Tumors can use an enzyme called ART1 to thwart antitumor immune cells, making the enzyme a promising new target for immunity-boosting cancer treatments, according to a new study.

Scientists have developed a genetic screening platform to identify genes that can enhance immune cells to make them more persistent and increase their ability to eradicate tumor cells.

Different activity in two molecular networks could help explain why triple negative breast cancers tend to be more aggressive in African American (AA) women compared with white American (WA) women, a new study suggests.

Treating cancer and other diseases with laser light is not currently considered routine, but new approaches using nanoparticles show some promise in improving existing techniques. Researchers review the status of the field and by combining photothermal therapy or photodynamic therapy with nanomaterials, they have been able to apply these types of phototherapies while also delivering drugs to sites in the body that are otherwise inaccessible. It is also possible to combine PTT and PDT into a single treatment, creating an even more powerful treatment method.

A new study suggests that the malaria drug hydroxychloroquine inhibits pathways that drive resistance to the chemotherapy agent cisplatin in head and neck cancers and restores tumor-killing effects of cisplatin in animal models.

Having dense breasts (more fibroglandular tissue than fatty tissue, as visualized on a mammogram) reduces the sensitivity of mammography by masking breast cancers and carries a 1.6- to 2.0-fold increased independent risk for breast cancer. To inform women about these risks, 38 U.S. states and the federal government have enacted legislation requiring a written dense breast notification (DBN) of a patient’s breast density after a mammogram, but there still is limited evidence about what breast density means, and what the implications are, to women. According to a new study, while women are receiving these notifications about their breast density, not all recipients are fully understanding what they mean in terms of future health implications. Boston University School of Medicine researchers suggest that knowledge about breast density and its associated risks is partly linked to women’s race/ethnicity and health literacy.

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers have now found an unusual way of stabilizing the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells.

Irradiation with fast protons is a more effective and less invasive cancer treatment than X-rays. However, modern proton therapy requires large particle accelerators, which has experts investigating alternative accelerator concepts, such as laser systems to accelerate protons. Such systems are deployed in preclinical studies to pave the way for optimal radiation therapy. A research team has now successfully tested irradiation with laser protons on animals.

New research has begun to unravel the mystery of why a particular form of leukaemia in infants has defied efforts to improve outcomes, despite significant improvements in treating older children. Scientists have now found subtle differences in the cell type that causes B acute lymphoblastic leukaemia (B-ALL) that may help to explain why some cases are more severe than others.

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Researchers have been able to re-engineer red blood cells and use them as a promising new vehicle for vaccine delivery.

Both nanomedicines and metronomic scheduling — when medications are given at lower, more frequent doses — can correct abnormalities surrounding tumors that help protect cancer cells and foster their growth and spread. Combining nanomedicines and metronomic scheduling may help improve cancer treatment strategies.

Scientists have identified a way to ’supercharge‘ tumor-attacking T cells, a finding that may not only improve the effectiveness of a promising type of cell-based cancer immunotherapy but also expand the number of cancers it can treat.

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers.

A recent study followed 515 patients with varying cancers. The goal was to evaluate if patients had an immune response to the Moderna mRNA-1273 vaccine and if that response differed by diagnosis and treatment.

New research has identified that the frequently used chemotherapy drug (5-FU or Fluorouracil) is 100 per cent more effective at targeting tumors (rather than surrounding tissues) when administered using an optimized liposomal formulation.

With the resurgence of interest in cancer metabolism, researchers are coming to realize that there is more to a cell’s biochemistry than once thought.

Scientists may better understand and test for the genetic variations that cause cancer and other heritable diseases through the application of federated analysis, a novel strategy for securely sharing and analyzing genomic data developed at the UC Santa Cruz Genomics Institute.

Metastatic cells form in a primary tumor and then break away from it, migrate to other organs, attach to them and form new tumors. This spread reduces patients‘ chances of recovery. Scientists have discovered some of the mechanisms by which these cells arise. This is due to cells that have narrowly escaped cell death (apoptosis) following a chemotherapeutic treatment. Those cells reprogram themselves to acquire metastatic skills. Thanks to this study, these cells – called PAME by the researchers – now appear as new therapeutic targets.

Amyloid beta, a protein known to build-up in the brains of Alzheimer’s patients, also helps skin cancer cells thrive when they spread to the brain, a new study finds.

Researchers have successfully leveraged an FDA-approved drug to halt growth of tumors driven by mutations in the RAS gene, which are famously difficult to treat and account for about one in four cancer deaths.