Schlagwort: HIV

HIV drug stabilizes disease progression in metastatic colorectal cancer

6. April 2022
Many cancers exhibit high levels of the reverse transcriptase enzyme. Single-agent lamivudine, a reverse transcriptase inhibitor, stopped disease progression in over 25% of patients with fourth-line refractory metastatic colorectal cancer. These results provide evidence for the evaluation of reverse transcriptase inhibitors as a new class of anti-cancer drugs.

Quelle: Sciencedaily

HIV drug stabilizes disease progression in metastatic colorectal cancer

6. April 2022
Many cancers exhibit high levels of the reverse transcriptase enzyme. Single-agent lamivudine, a reverse transcriptase inhibitor, stopped disease progression in over 25% of patients with fourth-line refractory metastatic colorectal cancer. These results provide evidence for the evaluation of reverse transcriptase inhibitors as a new class of anti-cancer drugs.

Quelle: Sciencedaily

New study reveals why HIV remains in human tissue even after antiretroviral therapy

27. März 2022
Thanks to antiretroviral therapy, HIV infection is no longer the life sentence it once was. But despite the effectiveness of drugs to manage and treat the virus, it can never be fully eliminated from the human body, lingering in some cells deep in different human tissues where it goes unnoticed by the immune system. Now, new research by University of Alberta immunologist Shokrollah Elahi reveals a possible answer to the mystery of why infected people can’t get rid of HIV altogether. Elahi and his team found that in HIV patients, killer T cells — a type of white blood cells responsible for identifying and destroying cells infected with viruses — have very little to none of a protein called CD73. Because CD73 is responsible for migration and cell movement into the tissue, the lack of the protein compromises the ability of killer T cells to find and eliminate HIV-infected cells, explained Elahi.

Quelle: Sciencedaily

HIV/Aids: Erste Frau gilt nach Stammzelltherapie als von HIV geheilt

17. Februar 2022
Zwei Männer wurden bereits erfolgreich von HIV geheilt, nun gilt auch eine Frau seit 14 Monaten als virusfrei. Bei ihr wurde eine andere Therapieform angewandt.

Quelle: SPIEGEL ONLINE

Scientists move HIV vaccine research forward by developing an immunogen that produces tier-2 antibodies

5. Februar 2022
Scientists take a promising step in the direction of developing an HIV vaccine using a unique native-like trimer to develop Tier-2 neutralizing antibodies — the kind that matter for combating HIV — in mice.

Quelle: Sciencedaily

Research breakthrough could see HIV drugs used to treat low-grade brain tumors

20. Dezember 2021
Drugs developed to treat AIDS and HIV could offer hope to patients diagnosed with the most common form of primary brain tumor. The breakthrough is significant because, if further research is conclusive, the anti-retroviral drugs could be prescribed for patients diagnosed with meningioma and acoustic neuroma brain tumors (also known as schwannoma).

Quelle: Sciencedaily

Solving mystery of rare cancers directly caused by HIV

14. Oktober 2021
For nearly a decade, scientists have known that HIV integrates itself into genes in cells that have the potential to cause cancer. And when this happens in animals with other retroviruses, those animals often develop cancer. But, perplexingly and fortunately, that isn’t regularly happening in people living with HIV. A new study reveals why doctors aren’t seeing high rates of T cell lymphomas — or cancers of the immune system — in patients with HIV.

Quelle: Sciencedaily

Blutspende: Großbritannien schafft diskriminierende Regel für viele Schwarze ab

12. Oktober 2021
In England mussten Blutspender bisher angeben, ob sie sexuelle Kontakte mit Personen aus Ländern hatten, in denen HIV grassiert. Diese Regel wurde als diskriminierend gegenüber Schwarzen empfunden.

Quelle: SPIEGEL ONLINE

A global assessment of cancer genomic alterations in epigenetic mechanisms

5. März 2015

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira

Abstract

Background

The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients.

Results

Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover a general trend in which transcriptional profiles and somatic mutations in tumor samples favor increased transcriptionally repressive histone methylation, and defective chromatin remodeling.

Conclusions

This unbiased approach confirms previously published data, uncovers novel cancer-associated aberrations targeting epigenetic mechanisms, and justifies continued monitoring of chromatin-related alterations as a class, as more cancer types and distinct cancer stages are represented in cancer genomics data repositories.

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