A trial found that taking a much higher dose of vitamin D than recommended for five years did not affect total mortality or the incidence of cardiovascular disease or cancer in older men and women.

Aggressive and relatively common lymphomas called diffuse large B cell lymphomas (DLBCLs) have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves, according to a new study.

Immunotherapies called chimeric antigen receptor (CAR) T cells use genetically engineered versions of a patient’s own immune cells to fight cancer. These treatments have energized cancer care, especially for people with certain types of blood cancers. Now, scientists have developed new CAR T cells that can do something their predecessors cannot: Make drugs.

Scientists have found a way to prove that biochemical signals sent from cell to cell play an important role in determining how those cells develop, findings that can help explain how stem cells differentiate and how cancer arises and proliferates, possibly leading to new treatments.

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration.

Scientists describe T. adhaerens‘ unusual behavior, including its capacity to repair its DNA even after significant radiation damage and to extrude injured cells, which later die. The findings advance scientific investigations of natural cancer-suppression mechanisms across life. Insights gleaned from these evolutionary adaptations may find their way into new and more effective therapies for this leading killer.

Using network modeling, researchers have honed in on a set of gene interactions that are critical to malignancy and likely to be fertile ground for broad cancer therapies.

Researchers have discovered that a nanoparticle therapeutic enhances cancer immunotherapy and is a possible new approach in treating malignant pleural effusion (MPE). MPE is the accumulation of fluid between the chest wall and lungs and is accompanied by malignant cells and/or tumors.

Depleting copper levels may reduce the production of energy that cancer cells need to travel and establish themselves in other parts of the body by a process referred to as metastasis, according to a new study. The discovery of the underlying mechanisms of how copper depletion may help reduce metastasis in breast cancer will help inform the design of future clinical trials.

Adding messenger RNA, or mRNA therapy improves the response to cancer immunotherapy in patients who weren’t responding to the treatment, new research shows. Immunotherapy uses the body’s immune system to prevent, control and eliminate cancer.

Patients with colorectal cancer were among the first to receive targeted therapies. These drugs aim to block the cancer-causing proteins that trigger out-of-control cell growth while sparing healthy tissues. But some patients are not eligible for these treatments because they have cancer-promoting mutations that are believed to cause resistance to these drugs. Now, physician-scientists have used computer modeling and cell studies to discover that more patients may be helped by a common class of targeted therapies than previously thought.

Driving up the immune response at the site of a cancer tumor with nanotechnology may help enhance immunotherapy treatments in advanced stages of the disease, new research in mice suggests.

Artificial intelligence (AI) models that evaluate medical images have potential to speed up and improve accuracy of cancer diagnoses, but they may also be vulnerable to cyberattacks. Researchers simulated an attack that falsified mammogram images, fooling both an AI breast cancer diagnosis model and human breast imaging radiologist experts.

Researchers have identified novel changes in gene network interactions associated with cancer that may lead to new treatment targets for chemotherapy. Their work shows that more than 90% of changes in gene network interactions in nine types of cancer studied are not detectable by current tests focused on changes in gene expression.

Researchers have demonstrated a major step forward in melding two key methods for studying breast cancer: one by genetic analysis and the second by looking at the architecture of cells, or their pathology. Using The Cancer Genome Atlas Breast Cancer Data set, they developed classification method that divides breast cancers into 12 distinct biological groups. This could aid future research efforts and enable faster translation of molecular findings into the pathology lab for clinical use, they report.

Sonodynamic therapy uses ultrasound in combination with drugs to release harmful reactive oxygen species (ROS) at the site of a tumor. However, the treatment isn’t very effective because cancer cells can activate antioxidant defense systems to counteract it. Now, researchers have breached these defenses with CRISPR/Cas9 gene editing, allowing sonodynamic therapy to effectively shrink tumors in a mouse model of liver cancer.

Good glucose control is important for reduction of cancer risk in obesity and type 2 diabetes. Large durable weight loss, as such, appears to afford protection against cancer, but with good glucose control the number of cancer cases also drops radically, a new study shows.

New research has implications for cancer research because it explains part of the paradox for how cells can transcribe genes in the absence of high-energy sources, a situation that unfolds in cancer and has puzzled researchers for years.

A recent study demonstrates that magnetic resonance imaging (MRI) and artificial intelligence (AI) can be used to detect early signs of tumor cell death in response to a novel virus-based cancer therapy.

A gene mutation linked to Alzheimer’s disease alters a signaling pathway in certain immune cells of individuals with the disease, according to a new study. The team also found that blocking the pathway — with a drug that’s currently being tested in cancer clinical trials — protects against many features of the condition in a preclinical model. The results could lead to new strategies to block the development of Alzheimer’s disease or slow its progression.

As an autoimmune disease, Type 1 diabetes raises important questions about immune cell activity that have broad implications for immunotherapy.

Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. Scientists now demonstrate how they can do the same thing at the molecular level, studying the ways cancer cells ‚talk‘ with one another.

In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study shows. This is a vital step toward a potentially curative treatment for a form of cancer affecting young children that is currently difficult to treat.

Immune checkpoint inhibitors strengthen the immune response against cancer cells, but the medications are ineffective against certain tumors. Results from a new clinical trial indicate that adding radiation may overcome this resistance to immune checkpoint inhibitors.

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique. Consequently, cells with mutated p53 have a survival advantage, which can cause cancer. Researchers have found new links between CRISPR, p53 and other cancer genes that could prevent the accumulation of mutated cells without compromising the gene scissors‘ effectiveness.