MEDIZIN.NEWZS.de – Quantum Related Diseases Research Group (QRDRG)

Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed cancers but resistance or intolerance to these molecules inevitably develop, leading to relapses. While studying a neglected tropical disease , Buruli ulcer, researchers discovered a novel therapeutic target for multiple myeloma that could allow to bypass this resistance.

When an individual suffers from cancer, the process of programmed cell death called apoptosis does not occur normally, permitting abnormal cells to thrive.

In a new study, researchers have identified the presence of a specific connection between a protein and an lncRNA molecule in liver cancer. By increasing the presence of the lncRNA molecule, the fat depots of the tumor cell decrease, which causes the division of tumor cells to cease, and they eventually die. The study contributes to increased knowledge that can add to a better diagnosis and future cancer treatments.

Research suggests that a vaccine stimulating production of a protein critical to the skin’s antioxidant network could help people bolster their defenses against skin cancer.

In Maryland wurde über Neujahr das erste Schweineherz der Welt in einen Menschen transplantiert. Paolo Brenner forscht an der Methode seit mehr als 25 Jahren. Hier erklärt er die Chancen dieses Verfahrens – und die Risiken.

Die US-Gesundheitsbehörde hat untersucht, ob Kinder nach einer Coronainfektion eher an Diabetes erkranken. Das Ergebnis: ein stark erhöhtes Risiko. Auf den ersten Blick wirkt das alarmierend, doch es gibt Kritik an der Studie.

Tertiary lymphoid structures are formations that occur outside of the lymphatic system. They contain immune cells and are similar in structure and function to lymph nodes and other lymphoid structures. However, little is known about how tertiary lymphoid structures form. In a new article published in Immunity, Moffitt Cancer Center researchers report on the molecular and cellular mechanisms that control tertiary lymphoid structure formation within tumors.

In den USA wütet Omikron besonders massiv und verursacht beispiellose Coronafallzahlen. Aus den Daten können Forscher Schlüsse über die Gefährlichkeit der neuen Mutante ziehen – im Vergleich zur Delta-Variante.

Ein Forschungsinstitut des US-Militärs testet einen Coronaimpfstoff, der vor Infektionen mit einer Vielzahl von Virusvarianten schützen soll. Erste Prüfungen am Menschen haben bereits stattgefunden.

80.430 Coronafälle sind laut dem Robert Koch-Institut innerhalb 24 Stunden registriert worden – die Zahl ist ein neuer Höchststand. Die bundesweite Sieben-Tage-Inzidenz überstieg erstmals die Marke von 400.

Um einen Großteil der Bevölkerung durchzuimpfen, fordert Wüst ein »klares Commitment der Ampel zur Impfpflicht«. Und: Ungeimpfte dürfen auf den Philippinen keine öffentlichen Verkehrsmittel benutzen. Der Überblick.

Versagen die billigen Antigen-Tests in der Omikron-Welle? Die neue Variante macht tatsächlich vieles anders – aber überflüssig werden die Schnelltests damit lange nicht.

Hier wird die ideologische Komplexität moderner Wissenschaft offengelegt: Sarah Richardson wirft einen kritischen Blick auf die Forschungen zu Effekten mütterlicher Prägung des heranwachsenden Fötus.

Scientists have provided new insights into molecular ‚crosstalk‘ in pancreas cancer cells, identifying vulnerabilities that could provide a target for therapeutic drugs already being studied in several cancers.

Acute myeloid leukemia (AML) is a cancer of white blood cells. Researchers discovered that AML cancer cells depend on a protein called SCP4 to survive. They think the previously little-known protein is involved in a metabolic pathway the cancer cells need to survive. SCP4 provides researchers with a potential new therapeutic approach for this aggressive cancer.

A new study reveals important insights into the molecular mechanisms that underpin the body’s natural defences against the development of skin cancer. The protein CSDE1 coordinates a complex chain of events that enable senescence in skin cells. The senescent cells act as a firewall against cancer, suppressing the formation of tumours. The findings are surprising because CSDE1 has been previously linked to driving the formation of cancers. The results offer new clues into the behavior of skin cancer at the cellular level, paving the way for potential new therapeutic targets to treat the disease.

Researchers have found that manipulating voltage patterns of tumor cells — using ion channel blockers already FDA-approved as treatments for other diseases — can in fact significantly reduce metastasis in animal models of breast cancer.

A research team has successfully repurposed an approved drug ifenprodil, a vasodilator, to be used in combination with the FDA-approved first-line drug sorafenib for hepatocellular carcinoma (HCC) treatment. This study leveraged on their CombiGEM-CRISPR v2.0 screening platform1 to expedite the search among the many possible drug combinations to inhibit druggable targets in the genome for treating HCC.

2021 wurden in Deutschland mehr als eine Million Todesfälle registriert – ein Rekordwert, allein im Dezember waren es gut 100.000. Die offizielle Corona-Statistik erklärt den Anstieg nur zum Teil.

Removing one type of T cell from donor blood used for stem cell grafts could greatly reduce a serious complication called graft-versus-host disease in patients with leukemia, according to a new study.

Nachdem bis zu 2000 Menschen in Köln mit abgelaufenem Impfstoff immunisiert wurden, bietet die Stadt erneute Impfungen für die Betroffenen an. Und: USA melden 1,35 Millionen Neuinfektionen – weltweiter Höchstwert.

»Da muss man vorsichtig sein«: Gesundheitsminister Lauterbach glaubt nicht, dass die Coronamaßnahmen in Deutschland für den Anstieg psychischer Störungen verantwortlich sind – und verweist auf die USA.

Researchers have developed an optical biopsy system that can distinguish between cancerous and healthy liver tissue. The technology makes use of diffuse reflectance spectroscopy and lifetime fluorescence measurements to evaluate makers of cellular metabolism that differ between healthy and cancerous cells. The system has higher accuracy than traditional biopsies, possibly making liver cancer diagnosis easier.

Researchers have successfully treated cancer in mice using metal catalysts that assemble anticancer drugs together inside the body. This study is the first report of therapeutic in vivo synthetic chemistry being used to make anticancer substances where they are needed simply by injecting their ingredients through a vein. Because this technique avoids indiscriminate tissue damage, it is expected to have a significant impact on cancer treatment.

Gesundheitsminister Lauterbach will überprüfen lassen, wie gut Schnelltests Omikron erkennen. Bis seine Liste steht, bleiben alle bislang empfohlenen Tests sinnvoll. Worauf Sie bei der Anwendung achten müssen.