Dear Readers To continue our conversation about cellular intelligence and mind in nature, please join me on twitter @jonlieffmd where there is a steady stream of new scientific articles and conversation.  You can also listen and watch the following recent podcast and YouTube interviews. The discussions are focused on my book, The Secret Language of […] Quelle: John Lieff, M.D

Why did you write The Secret Language of Cells? While studying signaling among brain cells, I became aware that all our cells—immune cells, gut cells, microbes, plant cells, etc. —are also constantly sending back and forth messages to each other in the same ways that neurons do. These conversations among cells outside of the brain […] Quelle: John Lieff, M.D

The Secret Language of Cells describes revolutionary findings about the interaction of the immune system and the brain and provides a new understanding of the relationship between mind and body. The immune system has a huge impact on the brain and mental health. Similarly, the brain strongly influences immune activity throughout the body. These interactions […] Quelle: John Lieff, M.D

  “The Secret Language of Cells … presents a new paradigm for understanding health and disease.” Andrew Weil, MD, director of the Andrew Weil Center for Integrative Medicine, professor at University of Arizona College of Medicine, and author This new paradigm, described in my upcoming book, The Secret Language of Cells, is based on the newly-recognized principle […] Quelle: John Lieff, M.D

It is only recently that scientists have been able to observe tiny viruses and their behavior. Bacteria are a thousand times larger than viruses, and our human cells are a thousand times larger than bacteria. We still don’t know what viruses are and how they can have such a complex lifestyle while consisting of just […] Quelle: John Lieff, M.D

Dear Reader,                      During a several year hiatus from writing new blog posts, I have completed my book, The Secret Language of Cells, which is due to be published this September. It is a synthesis, organization, and update of much of what I have written in my […] Quelle: John Lieff, M.D

The Secret Language of Cells takes us on an exciting journey into a world where we can visualize elaborate conversations among immune cells, brain cells, gut cells, bacteria, and even viruses. Dr. Lieff gives a wealth of examples for his thesis that this cellular signaling is the basis of life. It is a must read for anyone […] Quelle: John Lieff, M.D

2 documents really have to be written according to the quotations. It is not possible for them to make sure you an ordered composition will match your special directions because they don’t actually look at them. Whoever says your documents will pick on your own sense of assurance although writing them, along with your… Read More Quelle: John Lieff, M.D

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira Abstract Background The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients. Results Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover…

Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer1, Lothar Schermelleh and Marion Cremer Abstract Background A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome territories (CTs) in human and mouse somatic cells, and explored the spatio-temporal process of Barr body formation at onset of inactivation in early differentiating mouse embryonic stem cells (ESCs)….

Susanne Rittinghausen, Anja Hackbarth, Otto Creutzenberg, Heinrich Ernst, Uwe Heinrich, Albrecht Leonhardt and Dirk Schaudien Abstract Background Biological effects of tailor-made multi-walled carbon nanotubes (MWCNTs) without functionalization were investigated in vivo in a two-year carcinogenicity study. In the past, intraperitoneal carcinogenicity studies in rats using biopersistent granular dusts had always been negative, whereas a number of such studies with different asbestos fibers had shown tumor induction. The aim of this study was to identify possible carcinogenic effects of MWCNTs. We compared induced tumors with asbestos-induced mesotheliomas and evaluated their relevance for humans by immunohistochemical methods. Methods A total of 500…

Die Erreger von Infektionserkrankungen Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumanii und Pseudomonas aeruginosa haben zwei große Gemeinsamkeiten: Sie gehören zu den sogenannten gram-negativen Bakterien und sind in Krankenhäusern besonders gefürchtet. Wissenschaftler des Helmholtz-Instituts für Pharmazeutische Forschung Saarland (HIPS) und des Helmholtz-Zentrums für Infektionsforschung (HZI) in Braunschweig haben nun ein potenzielles neues Antibiotikum entdeckt, das gegen diese schwer zu bekämpfenden Bakterien wirkt. Ihre Ergebnisse veröffentlichten die Forscher im renommierten Journal Angewandte Chemie International Edition. Immer mehr Keime entwickeln Resistenzen gegen Antibiotika, sodass diese einstigen Wunderwaffen ihre Wirkungskraft verlieren. Vor allem in Krankenhäusern stellt die steigende Anzahl resistenter Keime das Personal vor…

Sehstörungen zählen mit zu den häufigsten Folgen eines Schlaganfalls. In seltenen Fällen tritt dabei der Verlust des räumlichen Sehens ein. Die Patienten nehmen die Welt um sich herum nur noch flach wie ein Bild wahr. Sie können keine Entfernungen mehr abschätzen, etwa wenn sie nach einer Tasse greifen oder sich ihnen auf der Straße ein Auto nähert. Diese Störung haben Forscher aus Saarbrücken um Professor Georg Kerkhoff und Anna-Katharina Schaadt mit Kollegen der Charité – Universitätsmedizin Berlin bei einem Patienten genauer untersucht. Sie haben nun erstmals ein wirksames Behandlungskonzept entwickelt und nachgewiesen, welches Hirnareal für diese Sehstörung verantwortlich ist. Die…