Biological condensates are small, membraneless organelles typically consisting of multiple proteins and nucleic acids within cells. They are involved in a diverse array of cellular processes but, despite their importance, methods to quantify their molecular makeup are lacking. Now, in a groundbreaking publication, researchers from the Brugués group at the Cluster of Excellence Physics of Life of Dresden University of Technology, the Leibniz Institute of Polymer Research Dresden, and the Max Planck Institute of Molecular Cell Biology and Genetics reveal a new experimental method to measure the molecular makeup of condensates.