The COVID-19 pandemic exposed critical deficiencies in the global health system and provides important lessons to improve preparedness for future emergencies. A case in point is Latin America, where access to testing was constrained by affordability and poor infrastructure. In recent months, three pivotal studies have converged to highlight critical vulnerabilities and lessons for global health resilience and equity. From diagnostic limitations in resource-limited settings to socioeconomic disparities in testing capacity, these findings underscore the need for collaborative and globally equitable health strategies.