Peroxidases are enzymes that break down hydrogen peroxide in organisms. Since their discovery in 1998, the electron source of „peroxiredoxin 6-type“ peroxidases for this reaction remained unclear. The research group of Professor Marcel Deponte at RPTU has now closed this knowledge gap. The researchers demonstrated in two model organisms – humans and malaria pathogens – that peroxiredoxin 6-type enzymes react rapidly with hydrosulfide, the anion of hydrogen sulfide. The study, funded by the German Research Foundation (DFG), was published in the journal „Advanced Science.“ The findings reveal a previously unknown connection between peroxide and sulfide metabolism.