Hamburg, 21 July 2025 – The world is facing an interconnected health crisis: zoonoses, antimicrobial resistance, environmental degradation, and climate change threaten millions of lives. An international expert group, the Lancet One Health Commission, warns in its first report of severe consequences if governments, business, and international organisations fail to change course immediately. The Bernhard Nocht Institute for Tropical Medicine (BNITM) played a key role as a leading partner. The central message: Only a consistent One Health approach – considering human, animal, and environmental health together – can break the escalating chain of health crises.