A global team of researchers led by Matthias Mann at the MPI of Biochemistry has made a groundbreaking discovery that saves the lives of patients suffering from toxic epidermal necrolysis (TEN). TEN is a rare but often fatal reaction to common medications, causing widespread detachment of the skin. Using spatial proteomics, the team identified the inflammatory JAK/STAT pathway as the main driver of disease. After validating their findings in pre-clinical models, they successfully treated the first seven patients worldwide with JAK inhibitors, all of which showed rapid and full recovery. This bench-to-bedside breakthrough study has been published in the Nature.