Brain organoids provide unique insights into the human brain. Now, the group of Jürgen Knoblich at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences, developed a new method that allows scientists to cultivate brain organoids with distinct cortical areas and front-to-back patterning. Together with collaborators at the Human Technopole and the University of Milan-Bicocca, they reported a method that gives scientists a deeper look into human-specific brain development and disorders. The new method is reported in Nature Methods on September 18.