Measles-Based Vector Vaccine Protects Mice against Influenza A (H7N9) Virus

Researchers at the Paul-Ehrlich-Institut (PEI), in cooperation with the Philipps-Universität Marburg, used the „recombinant measles vaccine virus“ vaccine platform to test vaccine candidates against the dangerous avian H7N9 influenza virus in an animal model. Vectored vaccines with a blueprint of haemagglutinin (H7) or neuraminidase (N9) induced specific antibodies in mice that could effectively inhibit H7N9 influenza viruses. H7-specific T cells were still detected in the animals two years after vaccination. Vaccination against H7 completely protected the mice against disease after infection. Vaccination against N9 mostly provided protection against a severe disease course.

Quelle: IDW Informationsdienst Wissenschaft