A major component of the cell’s protein destruction machine moonlights at brain synapses

A new study by researchers at the Max Planck Institute for Brain Research discovered a ‘moonlighting’ function carried out by a complex that normally works to degrade proteins in cells – this protein destruction machine is called the proteasome. The scientists found, by counting and visualizing individual protein complexes, that one part of the proteasome (the 19S regulatory complex) was abundant near brain synapses where it regulates synaptic proteins and transmission on its own – without its partner.