A breakthrough in fluorescence microscopy has been achieved by the research group of Ralf Jungmann at the Max Planck Institute of Biochemistry (MPIB) and Ludwig-Maximilians-Universität (LMU) Munich. The team developed Resolution Enhancement by Sequential Imaging (RESI), a revolutionary technique that enhances the resolution of fluorescence microscopy down to the Ångström scale. This innovation is poised to usher in a paradigm shift in our approach to study biological systems with thus far unprecedented detail.