Bitter-tasting herbal extracts have traditionally been used to support digestion, yet the molecular basis of their effects has remained largely unclear. The Leibniz Institute for Food Systems Biology at the Technical University of Munich has now gained new insights into this mechanism. Using a cellular model, its researchers demonstrated that herbal extracts can stimulate proton secretion in human gastric cells as key mechanism of gastric acid production, with combinations of extracts showing particularly strong effects. Extracts rich in polyphenols proved especially potent. The study further identified three human bitter taste receptor subtypes as key mediators of this response.