Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Synthetic Transfer Vehicles (STVs), an entirely new class of RNA transporters. To do so, they combined naturally occurring protein building blocks with synthetic protein structures designed using generative AI. Systematic screening identified STV-C8 as the most efficient candidate: In cell culture, it transports RNA far more efficiently than the lipid nanoparticles tested and can be adapted to different RNA cargoes and target cells. In animal models, the team demonstrated that the system also works in a living organism.