• Early life adversity, such as childhood trauma, abuse, or neglect, is one of the most powerful risk factors for developing psychiatric disorders later in life

• Male mice exposed to early life adversity developed deficits in social behavior, manifesting as social subordination

• Pharmacologically inhibiting the stress-modulating protein FKBP51 fully prevented these long-term social impairments – stressed mice receiving this treatment were indistinguishable from non-stressed controls

• This establishes FKBP51 as a critical pharmacological target for reversing the lasting impact of early trauma on brain function