Schlagwort: pancreatic cancer

Distinct classes of fibroblasts in tumors play opposing roles, promoting or restraining pancreatic cancer growth

30. März 2022
Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. Appropriately targeting these cells may offer options to improve treatment outcomes.

Quelle: Sciencedaily

Could diet modification make chemotherapy drugs more effective for patients with pancreatic cancer?

23. März 2022
The findings of a new study suggest that a ketogenic diet — which is low in carbohydrates and protein, but high in fat — helps to kill pancreatic cancer cells when combined with a triple-drug therapy. In laboratory experiments, the ketogenic diet decreased glucose (sugar) levels in the tumor, suggesting the diet helped starve the cancer. In addition, this diet elevated ketone bodies produced by the liver, which put additional stress on the cancer cells.

Quelle: Sciencedaily

Novel treatment makes pancreatic cancer susceptible to immunotherapy, mouse study shows

8. März 2022
A new study — in mice — suggests that blocking a major inflammatory pathway that is activated in pancreatic cancer makes the tumors sensitive to chemotherapy and a type of immunotherapy that prompts the immune system’s T cells to attack the cancer cells. The therapy more than doubled survival in a mouse model of pancreatic cancer.

Quelle: Sciencedaily

Pancreatic cancer cells feed off hyaluronic acid

28. Januar 2022
Hyaluronic acid, or HA, is a known presence in pancreatic tumors, but a new study shows that hyaluronic acid also acts as food to the cancer cells. These findings provide insight into how pancreatic cancer cells grow and indicate new possibilities to treat them.

Quelle: Sciencedaily

Researchers identify signaling mechanisms in pancreatic cancer cells that could provide treatment targets

12. Januar 2022
Scientists have provided new insights into molecular ‚crosstalk‘ in pancreas cancer cells, identifying vulnerabilities that could provide a target for therapeutic drugs already being studied in several cancers.

Quelle: Sciencedaily

Experimental drug boosts immunotherapy effectiveness in pancreatic cancer in mice

5. November 2021
An experimental drug enhanced the benefit of an immunotherapy to fight pancreatic cancer in mice by increasing the number of immune cells in the immediate vicinity of the tumor, leading to a reduction in tumor growth, and in some mice, eliminating their cancer.

Quelle: Sciencedaily

Scientists reverse pancreatic cancer progression in ‘time machine’ made of human cells

1. Oktober 2021
What makes pancreatic cancer so deadly is its covert and quick spread. Now, a ‚time machine‘ has shown a way to reverse the course of cancer before it spreads throughout the pancreas.

Quelle: Sciencedaily

Lab grown tumor models could improve treatment for pancreatic cancer

25. September 2021
An international team of scientists have created a three-dimensional (3D) pancreatic cancer tumour model in the laboratory, combining a bioengineered matrix and patient-derived cells that could be used to develop and test targeted treatments.

Quelle: Sciencedaily

A global assessment of cancer genomic alterations in epigenetic mechanisms

5. März 2015

Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira

Abstract

Background

The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients.

Results

Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover a general trend in which transcriptional profiles and somatic mutations in tumor samples favor increased transcriptionally repressive histone methylation, and defective chromatin remodeling.

Conclusions

This unbiased approach confirms previously published data, uncovers novel cancer-associated aberrations targeting epigenetic mechanisms, and justifies continued monitoring of chromatin-related alterations as a class, as more cancer types and distinct cancer stages are represented in cancer genomics data repositories.

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