Schlagwort: nucleic acids
Next-generation RNA switches through AI-based design: TU researchers develop a synthetic NAND switch in living cells
An interdisciplinary research team from two working groups at the Centre for Synthetic Biology at TU Darmstadt has developed the first RNA-based genetic switch that precisely replicates the logical behavior of a NAND gate, one of the most important building blocks of digital circuits. The results were published in the journal Nucleic Acids Research. Quelle: IDW Informationsdienst Wissenschaft
RNA-Schalter der nächsten Generation: Forschende entwickeln mit KI synthetischen NAND-Schalter in lebenden Zellen
Ein interdisziplinäres Forschungsteam aus zwei Arbeitsgruppen des Centre for Synthetic Biology der TU Darmstadt hat erstmals einen RNA-basierten genetischen Schalter entwickelt, der das logische Verhalten eines NAND-Gatters, eines der wichtigsten Bausteine digitaler Schaltungen, präzise nachbildet. Die Ergebnisse wurden im Fachjournal „Nucleic Acids Research“ veröffentlicht. Quelle: IDW Informationsdienst Wissenschaft
A global assessment of cancer genomic alterations in epigenetic mechanisms
Muhammad A Shah, Emily L Denton, Cheryl H Arrowsmith, Mathieu Lupien and Matthieu Schapira Abstract Background The notion that epigenetic mechanisms may be central to cancer initiation and progression is supported by recent next-generation sequencing efforts revealing that genes involved in chromatin-mediated signaling are recurrently mutated in cancer patients. Results Here, we analyze mutational and transcriptional profiles from TCGA and the ICGC across a collection 441 chromatin factors and histones. Chromatin factors essential for rapid replication are frequently overexpressed, and those that maintain genome stability frequently mutated. We identify novel mutation hotspots such as K36M in histone H3.1, and uncover…
Quantum entanglement between the electron clouds of nucleic acids in DNA
Rieper, Anders and Vedral modelled the electron clouds of nucleic acids in a single strand of DNA as a chain of coupled quantum harmonic oscillators with dipole-dipole interaction between nearest neighbours. As a main result, the entanglement contained in the chain coincides with the binding energy of the molecule. Derived in the limit of long distances and periodic potentials analytic expressions linking the entanglement witnesses to the energy reduction due to the quantum entanglement in the electron clouds. Rieper E, Anders J, Vedral V (2011) Quantum entanglement between the electron clouds of nucleic acids in DNA. arxiv.org/abs/1006.4053
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci
Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer1, Lothar Schermelleh and Marion Cremer Abstract Background A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome territories (CTs) in human and mouse somatic cells, and explored the spatio-temporal process of Barr body formation at onset of inactivation in early differentiating mouse embryonic stem cells (ESCs)….